Pimefylline Nicotinate

Chemical Name 3,7-dihydro-1,3-dimethyl-7-[2-[(3-pyridinylmethyl)amino] ethyl]-1H-purine-2,6-dione nicotinate 

77 g 7-( -bromoethyl)-theophylline C.A. 50, 12071f) and 57.8 g 3-picolylamine in 750 ml toluene were refluxed 16 hours with vigorous agitation. The 3-picolylamine hydrobromide formed was filtered off, and the filtrate was evaporated in a vacuum to about one-third of its original volume. About 300 to 400 ml diisopropyl ether were added, and the solution was seeded with a few pure crystals of the desired product. 

Common Name 7-((3-3 -picolylaminoethyl)theophylline nicotinate Structural Formula  

Chemical Abstracts Registry No. 10058-07-8 10001-43-1 (Base) TredeName Manufacturer Country 

To a solution of 130 parts cvclopropvl-di-(4-fluorophenyl)-carbinol in 240 parts benzene are added dropwise 43 parts thionyl-chloride. The whole is refluxed until no more gas is evolved. The reaction mixture is then evaporated. The residue is distilled in vacuo, yielding 4-chloro-1,1-di-(4-fluorophenyl)-1-butene, boiling point 165°C to 167°C at 6 mm pressure oq 1.5698 d2o 1.2151. 

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Bromoethyl)theophylline Pimefylline nicotinate 2-Bromo- -fluoro-17a 1 -dihydroxy-9/3,11/3-oxido-pregna-1,4-diene-3,20-dione-17,21 -acetate Halopredone acetate 1 -Bromo-5-hexanone Pentoxifylline... 

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