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Penicillin potassium salt

Whereas the carboxylic acid is shown for many of these compounds, the majority of the commercial penicillins are sodium salts. Penicillin G is available as the calcium salt [973-53-5] C gH N20 S d/s Ca, and as the potassium salt [113-98-4] C2gH2yN20 S K. [Pg.74]

The pH of the mixture was adjusted to 7.5 by adding a saturated sodium bicarbonate solution. After being washed twice with diethyl ether, the reaction solution was acidified to pH 2 with dilute hydrochloric acid and extracted with ether. The ether solution containing the free penicillin was washed twice with water and then extracted with 50 ml of N potassium bicarbonate solution. After freeze drying of the obtained neutral solution, the potassium salt of o-azidobenzylpenicillin was obtained as a slightly colored powder (11.2 grams, 54% yield) with a purity of 55% as determined by the hydroxylamine method (the potassium salt of penicillin G being used as a standard). [Pg.120]

Gomez etal. [160] have studied specific adsorption of potassium penicillin G (salt K) on Hg electrode from electrocapillary and capacity measurements. The Frumkin isotherm has been found applicable to the quantitative description of the data repulsive interaction parameter equaled —3.5 and standard free Gibbs energy of adsorption at the zero charge was —38.6 kJ mol h depended linearly... [Pg.981]

Benzyl penicillin (Penicillin G sodium and potassium salt) 0.5-5 MU IM/IV... [Pg.318]

The activity of penicillin G was originally defined in units. Crystalline sodium penicillin G contains approximately 1600 units per mg (1 unit = 0.6 meg 1 million units of penicillin = 0.6 g). Semisynthetic penicillins are prescribed by weight rather than units. The minimum inhibitory concentration (MIC) of any penicillin (or other antimicrobial) is usually given in mcg/mL. Most penicillins are dispensed as the sodium or potassium salt of the free acid. Potassium penicillin G contains about 1.7 mEq of K+ per million units of penicillin (2.8 mEq/g). Nafcillin contains Na +, 2.8 mEq/g. Procaine salts and benzathine salts of penicillin G provide repository forms for intramuscular injection. In dry crystalline form, penicillin salts are stable for years at 4°C. Solutions lose their activity rapidly (eg, 24 hours at 20°C) and must be prepared fresh for administration. [Pg.984]

The sodium and potassium salts are rapidly absorbed but give effective plasma concentrations for no more than 4 h. The procaine salt has a lower solubility and forms, on injection, a depot that slowly releases penicillin G, maintaining effective concentrations for up to 24 h. After intramuscular treatment of swine... [Pg.42]

The resulting solution was treated as described in Example 1 to give the potassium salt of a-azidobenzylpenicillin as a white powder (29.4 grams, 84% yield) with a purity of 83% as determined by the hydroxylamine method (the potassium salt of penicillin G being used as a standard). [Pg.493]

Approximately 1,000 g of phenoxymethylpenicillin acid (Penicillin V) is dissolved directly in about 5 liters of ethyl acetate to a concentration of 20% w/v. The resulting solution is filtered to remove any insoluble salts. The penicillin V acid (1,000 g) may also be obtained by extracting an aqueous solution of 1,110 g of the potassium salt of phenoxymethylpenicillin at a temperature of about 5°C, this solution being adjusted to pH 2-3 by the addition of 6 N sulfuric acid, twice with a total of 5 liters of ethyl acetate so that the final washed combined volume will have a concentration of about 20% w/v. The abovementioned ethyl acetate solution having a volume of about 5 liters is then dried with anhydrous Na2S04 and filtered to obtain a clear ethyl acetate solution of phenoxymethylpenicillin acid. [Pg.2652]

Cation toxicity Penicillins are generally administered as the sodium or potassium salt. Toxicities may be caused by the large quantities of sodium or potassium that accompany the penicillin. Sodium excess may result in hypokalemia. This can be avoided by using the most potent antibiotic, which permits lower doses of drug and accompanying cations. [Pg.314]

The penicillin-G-potassium salt has been oxidized using supported polyoxo-metallates.62 Specifically, the oxidation of the sulfide group to give the sulfoxide was achieved, the product being an intermediate in the production of Cephalosporin antibiotics.63 The selective oxidation of benzenethiol to benzenesulfonic acid with hydrogen peroxide was effectively catalysed by phosphotungstic acid on y-alumina.62 This was in contrast to the homogeneous oxidation where the disulfide was produced in substantial yields. [Pg.198]

Besides the group of psychotropic compounds, we must quote here the antibiotics as drugs where a rapid recent development of techniques can be observed. D.c. polarographic techniques for the determination of chloramphenicol [242], tetracycline [243] and streptomycin [244] are available. The polarographic determination of penicillin G potassium salt is only indirect and is preceded by the introduction of a nitroso group [245]. The synthesis of chloramphenicol comprises the chemical reduc-... [Pg.285]

FIGURE 1,12. (a) Chemical formula and (b) stereoview of the potassium salt of the benzyl derivative of the antibiotic penicillin. This crystallographic analysis established this chemical formula of penicillin showing that it contained, unexpectedly, a / -lactam (four-membered) ring. Circles representing atoms S, large stippled 0, small stippled N, small black C, small white K+, very small black hydrogen atoms omitted. [Pg.22]

The sodium and potassium salts of penicillin G are the only formulations suitable for i.v. administration. They are also the most rapidly absorbed... [Pg.23]

Penicillin G is available in injectable formulations. The sodium and potassium salts (crystalline penicillin) are water-soluble formulations and may be injected i.v., i.m. or s.c. They rapidly produce high plasma concentrations but have very short half-lives, so must be administered frequently. The potassium salt must be administered more carehilly than the sodium salt, as rapid i.v. administration can cause cardiac arrhythmias. These formulations are frequently used for their Grampositive activity in life-threatening diseases and conditions such as surgical colic, neonatal septicemia and clostridial myositis. [Pg.24]


See other pages where Penicillin potassium salt is mentioned: [Pg.1363]    [Pg.297]    [Pg.361]    [Pg.1363]    [Pg.297]    [Pg.361]    [Pg.305]    [Pg.121]    [Pg.1182]    [Pg.44]    [Pg.48]    [Pg.49]    [Pg.50]    [Pg.117]    [Pg.432]    [Pg.432]    [Pg.547]    [Pg.702]    [Pg.548]    [Pg.155]    [Pg.361]    [Pg.186]    [Pg.186]    [Pg.190]    [Pg.1368]    [Pg.153]    [Pg.217]    [Pg.219]    [Pg.3184]    [Pg.812]    [Pg.23]    [Pg.304]    [Pg.309]    [Pg.310]    [Pg.78]    [Pg.260]   
See also in sourсe #XX -- [ Pg.3184 ]




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Penicillin-G-potassium salt

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