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PDGFR

PDGF Isoforms consist of homo- and heterodimers of A- and B-polypeptide chains and homodimers of C- and D-polypeptide chains PDGFR Consists of PDGFR a and (3 receptors Embryonic development, particularly in the formation of the kidney, blood vessels, and various mesenchymal tissues. Proliferation of connective tissues, glial and smooth muscle cells... [Pg.566]

S orafenib (Nexavar ) Bayer TKI VEGFR, PDGFR, KIT, FTL-3, RAF Unresectable or metastatic renal cell carcinoma... [Pg.1193]

S unitinib (Sutent ) Pfizer TKI VEGFR, PDGFR, KIT, FLT-3, RET 1 matinib-resistant KIT overexpressing unresectable or metastatic gastro-intestinal stromal tumor... [Pg.1193]

Sorafenib is a multitargeted cancer therapy that inhibits VEGFR, PDGFR, KIT, fetal liver tyrosine kinase 3 (FLT-3), and the serine/threonine kinase RAF. RAF kinase is a key downstream effector of Ras in the MAPK/Ras signal-transduction pathway that has been linked to various cancers. Sorafenib is both a tyrosine kinase inhibitor and serine/threonine signal-transduction inhibitor. Sorafenib has been approved in renal cancer. [Pg.1194]

Sunitinib is also a multitargeted cancer therapy targeting VEGFR, PDGFR, KIT, FLT-3, and RET. Sunitinib has been approved in GIST refractory to imatinib and renal cancer. [Pg.1194]

Sorafenib (Nexavar) TKI Raf, VEGFR2, c-Kit, PDGFR, Flt-3, FGFR1 Inhibition of kinase activity - ATP-competitive RCC... [Pg.1255]

PDGFR Platelet-derived growth factor receptor... [Pg.285]

Board, R. and Jayson, G. 2005. Platelet-derived growth factor receptor (PDGFR) a target for anti cancer therapeutics. Drug Resistance Updates 8(1-2), 75-83. [Pg.289]

The extracellular domain of RPTKs can be composed of different structural motifs. For instance, the EGFR extracellular domain contains two cysteine-rich regions. The PDGFR extracellular domain consists of five immuno-globulin-like repeats. Other domains found in the extracellular region of RPTKs include fibronectin III repeats,... [Pg.419]

PDGFR platelet-derived growth factor receptor RAGS repulsive axon guidance signal... [Pg.966]

PDGFR Overexpression and autocrine stimulation. Activation of blood vessel smooth muscle cells in the media Glioblastomas, Restenosis, Atherosclerosis... [Pg.4]

See other pages where PDGFR is mentioned: [Pg.156]    [Pg.568]    [Pg.569]    [Pg.985]    [Pg.1192]    [Pg.1193]    [Pg.1194]    [Pg.1194]    [Pg.1256]    [Pg.1271]    [Pg.240]    [Pg.4]    [Pg.514]    [Pg.179]    [Pg.419]    [Pg.419]    [Pg.421]    [Pg.422]    [Pg.423]    [Pg.423]    [Pg.426]    [Pg.432]    [Pg.453]    [Pg.2]    [Pg.4]    [Pg.5]    [Pg.5]    [Pg.6]    [Pg.9]    [Pg.10]    [Pg.12]    [Pg.12]    [Pg.13]    [Pg.506]    [Pg.518]    [Pg.544]   
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Kinase PDGFR

PDGFR (platelet-derived growth

PDGFR (platelet-derived growth receptors

PDGFR factor receptor

PDGFR receptor

Platelet-derived growth factor receptor PDGFR)

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