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Kinase PDGFR

STI 571 <322> (<322>, a phenylaminopyrimidine derivative, a potent inhibitor of the Abl tyrosine kinase, PDGFR kinases and c-Kit tyrosine kinases [705] <322> designed to inhibit ABL and BCR-ABL tyrosine kinases, inhibition through competitive ATP-binding pocket interactions [706] <322> use un second-line therapy of small-cell lung cancer, inhibits c-kit kinase, resulting in an metabolic change of tumor cells [706]) [705, 706]... [Pg.542]

Sorafenib is a multitargeted cancer therapy that inhibits VEGFR, PDGFR, KIT, fetal liver tyrosine kinase 3 (FLT-3), and the serine/threonine kinase RAF. RAF kinase is a key downstream effector of Ras in the MAPK/Ras signal-transduction pathway that has been linked to various cancers. Sorafenib is both a tyrosine kinase inhibitor and serine/threonine signal-transduction inhibitor. Sorafenib has been approved in renal cancer. [Pg.1194]

Sorafenib (Nexavar) TKI Raf, VEGFR2, c-Kit, PDGFR, Flt-3, FGFR1 Inhibition of kinase activity - ATP-competitive RCC... [Pg.1255]

SU11248 Tyrosine kinase inhibitor, VEGFR, PDGFR, Kit... [Pg.453]

Sorafenib Renal cell Raf/PDGFR/VEGFR/KIT kinase inhibitor 2... [Pg.14]

Sunitinib Renal cell, gastrointestinal PDGFR/VEGFR/KIT/Flt3 kinase inhibitor 7... [Pg.14]

See other pages where Kinase PDGFR is mentioned: [Pg.491]    [Pg.414]    [Pg.491]    [Pg.414]    [Pg.156]    [Pg.569]    [Pg.985]    [Pg.1192]    [Pg.1194]    [Pg.1256]    [Pg.240]    [Pg.4]    [Pg.514]    [Pg.179]    [Pg.419]    [Pg.423]    [Pg.2]    [Pg.5]    [Pg.5]    [Pg.6]    [Pg.9]    [Pg.10]    [Pg.12]    [Pg.12]    [Pg.13]    [Pg.506]    [Pg.518]    [Pg.544]    [Pg.67]    [Pg.165]    [Pg.719]    [Pg.117]    [Pg.86]    [Pg.101]    [Pg.343]    [Pg.344]    [Pg.347]    [Pg.350]    [Pg.358]    [Pg.360]    [Pg.363]    [Pg.365]    [Pg.385]    [Pg.393]   
See also in sourсe #XX -- [ Pg.123 ]



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PDGFR

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