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PDGFR platelet-derived growth receptors

PDGFR Platelet-derived growth factor receptor... [Pg.285]

PDGFR platelet-derived growth factor receptor RAGS repulsive axon guidance signal... [Pg.966]

Figure 5. Crosstalk mechanisms involving sphingosine 1-phosphate (SIP) or lysophosphatidic acid (LPA). GRK2, G-protein coupled receptor kinase 2. PDGF, platelet-derived growth factor. PDGFR, platelet-derived growth factor receptor. SIP, sphingosine 1-phosphate receptor 1. MAPK, mitogen-activated protein kinase, a., alpha subunit of the heterotrimeric inhibitory G-protein, G.. py, beta/gamma subunits of a heterotrimeric G-protein. Figure 5. Crosstalk mechanisms involving sphingosine 1-phosphate (SIP) or lysophosphatidic acid (LPA). GRK2, G-protein coupled receptor kinase 2. PDGF, platelet-derived growth factor. PDGFR, platelet-derived growth factor receptor. SIP, sphingosine 1-phosphate receptor 1. MAPK, mitogen-activated protein kinase, a., alpha subunit of the heterotrimeric inhibitory G-protein, G.. py, beta/gamma subunits of a heterotrimeric G-protein.
Board, R. and Jayson, G. 2005. Platelet-derived growth factor receptor (PDGFR) a target for anti cancer therapeutics. Drug Resistance Updates 8(1-2), 75-83. [Pg.289]

Imatinib (STI571) is an inhibitor of the tyrosine kinase domain of the Bcr-Abl oncoprotein and prevents the phosphorylation of the kinase substrate by ATP. It is indicated for the treatment of chronic myelogenous leukemia (CML), a pluripotent hematopoietic stem cell disorder characterized by the t(9 22) Philadelphia chromosomal translocation. This translocation results in the Bcr-Abl fusion protein, the causative agent in CML, and is present in up to 95% of patients with this disease. This agent inhibits other activated receptor tyrosine kinases for platelet-derived growth factor receptor (PDGFR), stem cell factor (SCF), and c-kit. [Pg.1307]

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See also in sourсe #XX -- [ Pg.236 ]



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