Particle beam liquid chromatography spectrometry

Table 5.7 Theoretically predicted polypeptides from the trypsin digestion of S-lacto-globulin (/3LG) . Reprinted from J. Chromatogr., A, 763, Turula, V. E., Bishop, R. T., Ricker, R. D. and de Haseth, J. A., Complete structure elucidation of a globular protein by particle beam liquid chromatography-Fourier transform infrared spectrometry and electrospray liquid chromatography-mass spectrometry - Sequence and conformation of /3-lactoglobulin , 91-103, Copyright (1997), with permission from Elsevier Science...

C.J. Miles, D.R. Doerge and S. Bajic, Particle beam liquid chromatography-mass spectrometry of national pesticide survey analytes, Archives Environmental Contamination Toxicol., 22 (1992) 247-251. 

This technique is complementary to the thermospray technique. Relative advances of the particles beam technique over thermospray include library searchable electron impact spectra, improved reproducibility, easier use and increased predictability over a broad range of compounds. But since a particle beam requires same sample volatility, very large and polar compounds such as proteins may not provide satisfactory results using particle beam liquid chromatography-mass spectrometry. Additionally, certain classes of compounds such as preformed ions, azo dyes and complex sugars may not yield satisfactory electron impact spectra, but can be run on thermospray. In other words, both liquid chromatography-mass spectrometry techniques complement each other s limitations and the analyst may want to add both to address a broader range of samples. 

J Yinon, TL Jones, LD Betowski. Particle beam liquid chromatography electron impact mass spectrometry of dyes. J Chromatogr 482 75-85, 1989. 

D Hurtaud, B Delepine, P Sanders. Particle-beam liquid chromatography-mass spectrometry method with negative ion chemical ionization for the confirmation of oxacillin, cloxacillin and dicloxacillin residues in bovine muscle. Analyst 119 2731-2736, 1994. 

P.J. Kijak, M.G. Leadbetter, M.H. Thomas, E.A. Thomson, Confirmation of oxytetracycline, tetracycline and chlortetracycline residues in milk by particle-beam liquid chromatography-mass spectrometry, Biol. Mass Spectrom., 20 (1991) 789. 

Tinke, A.P. Van der Hoeven, R.A.M. Niessen, W.M.A. Tjaden, U.R. Van der Greet, J. Some aspects of peak broadening in particle-beam liquid-chromatography mass-spectrometry. J. Chromatogr. 1991, 554, 119-124. 

Turnipseed, S.B. Roybal, J.E. Rupp, H.S. Hurlbut, J.A. Long, A.R. Particle-beam liquid-chromatography mass-spectrometry of triphenylmethane dyes—Application to confirmation of malachite green in incurred catfish tissue. J. Chromatogr. 1995, 670, 55-62. 

Particle Beam Liquid Chromatography/Mass Spectrometry of Phenols and Their Sulfate and Glucuronide Conjugates... 

The particle beam-liquid chromatography-mass spectrometry (PB-L0-M8) of phenols (phenol, 4-nitrophenol, and 1—naphthol) and their glucuronide and sulfate conjugates in electron impact (El) and positive chemical ionization (PCI) is described. 

C. S. Creaser and J. W. Stygall, Particle beam liquid chromatography-mass spectrometry instrumentation and applications—a review. Analyst 118, 1467-1480 (1993). 

Jones and co-workers [228] used particle beam liquid chromatography coupled with a MS detector to determine styrene oligomers up to the w-18 oligomer of PS. Bryant and Semiyen [229] analysed cyclic oligomers of polybutylene terephthalate using column chromatography GPC (size exclusion), fast atom bombardment mass spectrometry, and tandem mass spectrometry (MS-MS). They obtained molecular weight distributions. 

M Careri, MT Lugari, A Mangia, P Manini, S SpagnoU. Identification of vitamin A, vitamin D and vitamin E by particle-beam liquid chromatography mass spectrometry. Fresenius J Anal Chem 351 768-776, 1995. 

Particle beam liquid chromatography mass spectrometry has been used to determine up to nl8 oligomers in polystyrene. ... 

See footnote cto Table3 LC/PB/MS = hquid chromatography/particle beam mass spectrometry LC/APcl/ESl-MS/MS = liquid chromtography/atmospheric pressure chemical ionization/electrospray ionization tandem mass spectrometry LC/FTIR = Fourier transform infrared LC/TSP-MS/MS = liquid chromatography/thermospray tandem mass spectrometry LC/TSP-MS = liquid chromatography/thermospray mass spectrometry. 

R.D. Voyksner, C.S. Smith and P.C. Knox, Optimization and application of particle beam high-performance liquid chromatography/mass spectrometry to compounds of pharmaceutical interest, Biomed. Environ. Mass Spectrom., 19 (1990) 523-534. 

T.A. Bellar, T.D. Behymer and W.L. Budde, Investigation of enhanced ion abundances from a carrier process in high-performance liquid chromatography particle beam mass spectrometry, J. Am. Soc. Mass Spectrom., 1 (1990) 92-98. 

Based on a new technology, particle beam enhanced liquid chromatography-mass spectrometry expands a chemist s ability to analyse a vast variety of substances. Electron impact spectra from the system are reproducible and can be searched against standard or custom libraries for positive compound identification. Chemical ionization spectra can also be produced. Simplicity is a key feature. A simple adjustment to the particle beam interface is all it takes. 

Di Corcia and Marchetti [160] determined chlorinated phenoxy acid and ester type herbicides in amounts down to lmg kg-1 or lower in soil by liquid chromatography combined with particle beam mass spectrometry and ultraviolet absorption spectrometry. 

Kim et al. [161] determined chlorinated phenoxy and ester herbicides in sediments at the mg k 1 level using particle beam mass spectrometry in conjunction with liquid chromatography. 

Coupling of liquid chromatography with mass spectrometry provides unequivocal online spectrometric identification of tetracycline antibiotics in animal-derived foods. Typical applications of mass spectrometry in confirming tetracycline residues in edible animal products describe coupling of liquid chromatography with mass spectrometry via particle-beam (280), electrospray (292), or atmospheric pressure chemical ionization (307), using negative-ion detection interfaces. 

M Careri, A Mangia, P Manini, N Taboni. Determination of phylloquinone (vitamin K,) by high performance liquid chromatography with UV detection and with particle beam-mass spectrometry. Fre-senius J Anal Chem 355 48-56, 1996. 

M Careri, R Cilloni, MT Lugari, P Manini. Analysis of water-soluble vitamins by high-performance liquid chromatography-particle beam-mass spectrometry. Anal Commun 33 159-162, 1996. 

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