Parathyroid hormone fragment

Yin J, Chu JW, Ricci MS, Brems DN, Wang DI, Trout BL. Effects of antioxidants on the hydrogen peroxide-mediated oxidation of methionine residues in granulocyte colony-stimulating factor and human parathyroid hormone fragment 13-34. Pharm Res 2004 21 (12) 2377—2383. 

TransPharma-Medical, an Israeli-based pharmaceutical company, is investigating the transdermal delivery of human parathyroid hormone fragment for the treatment of osteoporosis in addition to the delivery of human growth hormone [41], This technology utilizes a 1-cm2 patch that creates small channels or holes in the stratum... 

In order to determine the optimum sample preparation conditions, we initially tried several sample preparation methods in the absence of contaminants. The following peptide and protein mixture was prepared (peptides and protein were purchased from Sigma Chemicals, St. Louis, MO) 1 pmol/jul Parathyroid Hormone Fragment 39-68 (PHF), MW = 3285.7, 10 pmol/ul Pigeon Heart Cytochrome C (PHC), MW = 12,173, and 10 pmol/ul Bovine Serum Albumin (BSA), MW = 66,256. A saturated solution of Sinapinic acid in 1 1 ethanol water was used as matrix. 

Fig 1. 1 pmol Parathyroid Hormone Fragment 39-68 (PHF), lOpmoI Pigeon Heart Cytochrome C (PHC), 10 pmol Bovin Serum Albumin (BSA) in saturated sinapinic acid matrix, desorbed from a. Polyethylene Membrane 113-2 b. Polypropylene Membrane 1222 c. Type 61 Disposable IR Card d. C8 Extraction Disk e. C18 Extraction Disk. 

Mallette LE. Synthetic human parathyroid hormone 1-34 fragment for diagnostic testing. Ann Intern Med 1988 109(10) 800-4. 

Whitfield J, Morley P, Willick G. The parathyroid hormone, its fragments and analogues—potent bone-builders for treating osteoporosis. Expert Opin Investig Drugs 2000 9(6) 1293-315. 

A non-(l-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples. Clin. Chem. (1998) 44 805-809. 

The major function of the parathyroid hormone (PTH parathormone) is to regulate the concentration of extracellular calcium. PTH is heterogeneous and circulates as an intact polypeptide and as fragments. The major circulating biologically active peptide is intact PTH, which is rapidly cleared from the circulation (half-life less than 10 min). The N-terminal portion is responsible for its biologic activity. 

Welch SP, Dewey WL (1990) The activity of several peptide fragments of parathyroid hormone, alone and in combination with salmon caldtonin and morphine, in antinociceptive tests in the mouse. J Pharmacol Exp Ther 252 140-146... 

Adrenocorticotropic hormone (ACTH), insulin, and parathyroid hormone (PTH) are examples of polypeptide or protein hormones. They are generally water soluble and circulate freely in plasma as the whole molecule or as active or inactive fragments. The half-life of these hormones in plasma is quite short (10 to 30 minutes or less), and wide... 

Figure 49-10 Amino acid sequence of preproparathyroid hormone. Arrows indicate the sites of cleavage by proteases to remove the N-terminal methionines (/), the leader (pre) sequence (2), and the pro sequence (3), producing intact PTH (1-84). Cleavage at position 4 produces inactive carboxyl (C)-terminai fragments. (From Habener JF, Rosenblatt Ni, Potts JT Jr. Parathyroid hormone Biochemical aspects of biosynthesis, secretion, action, and metabolism. Physiol Rev 1984 64 985-1053.)...

Figure 49-12 Secretion, metabolism, clearance, and circulating forms of PTH. Both intact PTH and inactive fragments containing the middle and carboxyl (C)-terminal amino acids are secreted by the parathyroid glands.These inactive fragments are also produced by peripheral metabolism of intact PTH by the liver and kidneys. Carboxyl fragments are cleared by the kidneys by glomerular filtration.The half-life and concentration of intact hormone are small compared with those of inactive fragments. (From Endres DB, Villanueva R, Sharp CF jr. Singer FR. Measurement of parathyroid hormone. Endocrinol Metab Clin North Am 1989 18 611-29.)...

Mallette LE, Tuma SN, Berger RE, Kirkland JL. Radioimmunoassay for the middle region of human parathyroid hormone using an homologous antiserum with a carboxy-terminal fragment of bovine parathyroid hormone as radioligand. J Clin Endocrinol Metab 1982 54 1017-24. 

Parathyroid hormone is an 84 amino acid, li ear polypeptide secreted by the parathyro gland. Early structure activity studies showt that the amino-terminal region consisting 34 residues was sufficient for full biologic activity (96, 97). This fragment could furtb be divided into three distinct regions (1)T1... 

Teriparatide - recombinant fragment of parathyroid hormone osteoporosis Tetracycline - antibiotic... 

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