Antinociceptive test

Structure of a new series related to prodilidine (XXIX) closely resembles (XXVlIa) [105]. Its analgesic potency in rats, assessed by an antinociceptive test, is over... 

Hydrazone derivatives of naloxone and naltrexone produce a remarkably long blockade of opioid receptors as judged by binding and antinociceptive tests 52 (oxymorphuzonc, the /V-mclhyl analog, produced prolonged analgesia... 

All compounds that behave as narcotic analgesics characterized by the usual criteria contain a basic nitrogen center that either forms parts of an alicyclic ring system, as in morphine and pethidine, or terminates an acyclic chain, as in methadone, etonitazene, and the enkephalins. Nonbasic compounds of high activity in antinociceptive tests invariably fail to satisfy criteria for narcotic analgesics, such as reversal of effects by naloxone or nalorphine or evidence of binding to opioid receptors recent examples are the barbiturate... 

Welch SP, Dewey WL (1990) The activity of several peptide fragments of parathyroid hormone, alone and in combination with salmon caldtonin and morphine, in antinociceptive tests in the mouse. J Pharmacol Exp Ther 252 140-146... 

Electrical stimulation of the tooth pulp in dogs was first used as an antinociceptive test in 1938 [42], and the method has since been modified and used widely in the guinea-pig [43]. Nociceptive electrical stimuli have been applied to a variety of anatomical areas, including the rat scrotal sac [44], the mouse tail [45] and rectum of the rat [46] in each case, vocalization by the test animal is used as the test end-point. 

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