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Parathyroid hormone, human

Brewer, H. B. Falrwell, T. Ronan, R. Sizemore, 6. W. Arnaud, C. D. "Human Parathyroid Hormone Amlno-Acld Sequence of the Amlno-Termlnal Residues 1-34". Proc. Natl. Acad. Sci. IBA, (1972), 69, 3585-3588. [Pg.54]

J. T. Jr. "The Amlno-Acld Sequence of the Amlno-Termlnal 37 Residues of Human Parathyroid Hormone". Proc. Natl. [Pg.54]

Teriparatide, recombinant human parathyroid hormone) 1-34), is the first anabolic agent approved by the FDA for treatment of... [Pg.863]

Human parathyroid hormone (hPTH) is an 84 amino acid polypeptide that functions as a primary regulator of calcium and phosphate metabolism in bones. It stimulates bone formation by osteoblasts, which display high-affinity cell surface receptors for the hormone. PTH also increases intestinal absorption of calcium. [Pg.324]

Teriparatide is a recombinant product representing the first 34 amino acids in human parathyroid hormone. Teriparatide increases bone formation, the bone remodeling rate, and osteoblast number and activity. Both bone mass and architecture are improved. [Pg.42]

Other SERMs are currently under development. Diaz Curiel et al. (1998) have proved that a raloxifene analog, LY117018 HC1, is effective in reducing bone loss in OVX rats. In addition, the administration of the substance permits a significant reduction in the minimal effective dose of human parathyroid hormone (PTHh) required in the treatment of osteopenic rats (Hodsman et al. 1999a,b). Two more compounds, FC1271a 41 and HMR-3339 (Ammann et al. 2004), show promising results in preclinical studies. [Pg.199]

T Kimura, M Takai, Y Masui, T Morika, S Sakakibara. Strategy for the synthesis of large peptides an application to the total synthesis of human parathyroid hormone [hPTH (1-84)]. Biopolymers 20, 1823, 1981. [Pg.260]

Y. Nabuchi, E. Fujiwara, H. Kuboniwa, Y. Asoh, H. Ushio, The Stability and Degradation Pathway of Recombinant Human Parathyroid Hormone Deamidation of Asparaginyl Residue and Peptide Bond Cleavage at Aspartyl and Asparaginyl Residues , Pharm. Res. 1997, 14, 1685-1690. [Pg.374]

S.4.2.2.2.2 Biotinylated Human Parathyroid Hormone through ThiazoKdme Ring Formation... [Pg.90]

Human parathyroid hormone, a 34-residue peptide, has an N-terminal Ser suitable for conversion into the /V -glyoxyl moiety, thus, permitting a subsequent thiazolidine conjugation with 1-amino-2-thiol derivatized biotin.[l7 ... [Pg.90]

Nabnchi, Y, E. Eujiwara, K. Ueno, H. Knboniwa,Y. Asoh, and H. Ushio, Oxidation of recombinant human parathyroid hormone effect of oxidized position on the biological activity. Pharm Res, 1995.12(12) 2049-52. [Pg.62]

Yin J, Chu JW, Ricci MS, Brems DN, Wang DI, Trout BL. Effects of antioxidants on the hydrogen peroxide-mediated oxidation of methionine residues in granulocyte colony-stimulating factor and human parathyroid hormone fragment 13-34. Pharm Res 2004 21 (12) 2377—2383. [Pg.306]

E. coft-expressed recombinant human parathyroid hormone]... [Pg.314]

Mallette LE. Synthetic human parathyroid hormone 1-34 fragment for diagnostic testing. Ann Intern Med 1988 109(10) 800-4. [Pg.501]

Mallette LE, Kirkland JL, Gagel RF, Law WM Jr, Heath H 3rd. Synthetic human parathyroid hormone-(l-34) for the... [Pg.501]

Winer KK, Yanovski JA, Cutler GB Jr. Synthetic human parathyroid hormone 1-34 vs calcitriol and calcium in the treatment of hypoparathyroidism. JAMA 1996 276(8) 631-6. [Pg.502]

Body JJ, Gaich GA, Scheele WH, Kulkarni PM, Miller PD, Peretz A, Dore RK, Correa-Rotter R, Papaioannou A, Cumming DC, Hodsman AB. A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)] with alendronate in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 2002 87(10) 4528-35. [Pg.502]

Hodsman AB, Hanley DA, Ettinger MP, Bolognese MA, Fox J, Metcalfe AJ, Lindsay R. Efficacy and safety of human parathyroid hormone (1-84) in increasing bone... [Pg.502]

Tashjian AH Jr, Chabner BA. Commentary on clinical safety of recombinant human parathyroid hormone 1-34 in the treatment of osteoporosis in men and postmenopausal women. J Bone Miner Res 2002 17(7) 1151-61. [Pg.502]

Vahle JL, Sato M, Long GG, Young JK, Francis PC, Engelhardt JA, Westmore MS, Linda Y, Nold JB. Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety. Toxicol Pathol 2002 30(3) 312-21. [Pg.502]

Frolik CA, Black EC, Cain RL, et al. Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure. Bone. 2003 33 372-379. [Pg.473]

The use of commercial kits eliminates the time required to produce and characterize Ab reagents. However, method validation must be conducted to show that the kit developed for diagnostic use is suitable for the intended PK study application. The kit selection and method validation processes are illustrated here for the bio-analytical application of a recombinant human parathyroid hormone (rhPTH) drug, ALX1-11 (Preos , NPS Pharmaceuticals). [Pg.169]

Deal, C. 2004. The use of intermittent human parathyroid hormone as a treatment for osteoporosis. Curr. Rheumatol. Rep. 6 49—58. [Pg.323]

Recombinant human parathyroid hormone (1-34) Identical sequence to the 34N-terminal amino acids of the 84-amino acid human parathyroid hormone... [Pg.450]

Teriparatide is a recombinant human parathyroid hormone which promotes bone growth. It is available in the form of an injection and only prescribed by osteoporosis specialists. NICE have issued guidance on who is eligible to receive it. [Pg.272]

Teriparatide (a recombinant human parathyroid hormone) stimulates bone formation and is given daily by subcutaneous injection. There is evidence that teriparatide reduces vertebral and non-vertebral fractures. NICE recommends that it should be considered for the secondary prevention of osteoporotic fragility fractures in women aged 65 years and over who are intolerant of... [Pg.438]

TransPharma-Medical, an Israeli-based pharmaceutical company, is investigating the transdermal delivery of human parathyroid hormone fragment for the treatment of osteoporosis in addition to the delivery of human growth hormone [41], This technology utilizes a 1-cm2 patch that creates small channels or holes in the stratum... [Pg.804]

See other pages where Parathyroid hormone, human is mentioned: [Pg.54]    [Pg.861]    [Pg.162]    [Pg.294]    [Pg.294]    [Pg.315]    [Pg.326]    [Pg.59]    [Pg.760]    [Pg.19]    [Pg.90]    [Pg.179]    [Pg.500]    [Pg.471]    [Pg.170]    [Pg.510]    [Pg.439]   
See also in sourсe #XX -- [ Pg.324 ]

See also in sourсe #XX -- [ Pg.277 , Pg.298 , Pg.309 ]

See also in sourсe #XX -- [ Pg.71 ]



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