Pangamic acid

B 5 Pangamic acid, reported to enhance oxygen uptake... 

Vitamins B, (pantothenic acid), Bg (pyridoxine). By (biotin), Bg (inositol), B,o (para-aminobenzoic acid), Bn (choline), lecithin, and Bi5 (pangamic acid) are Usted here for sake of completeness but not shown in the table.The reader is referred to http //www.acu-ceU.com for examples. 

Speaking further of garlie, in a brief section about laetrile, garlic is disparagingly cited as an alternative health product in T. Colin Campbell s The China Study, as assisted by Thomas M. Campbell II (Campbell, 2005, p. 252). Mention is made of pangamic acid, various bee concoctions, and of zinc supplements, which also may have no apparent benefit. 

Pangamic acid (6-0-(dimethylaminoacetyl)-D-gluconic acid) (10) has also been isolated from C. arietinum and is reported to have anti-stress and anti-hyperlipidemic activity [20]. 

Pabryn, H-5 Pachybiose, P-1 Pacfayman, G-240 Pacbymatismin, P-2 Palatinose, G-296 Paldimycin, P-3 Palmitoylcoenzyme A, C-144 Palohex, 1-32 Panavirin, A-796 Pandermin, H-128 Pangamic acid, P-4 Panimycin, D-625 Panose, P-5... 

A number of other chemical substances of an organic nature have been included in the vitamin B complex. These include inositol, orotic acid, lipoic acid, rutin, carnitine and pangamic acid, but it is doubtful whether these compounds have much practical significance in the nutrition of farm animals. 

Elemental analysis and i.r. spectroscopy have indicated that pangamic acid (vitamin Bjg) is 6-0-(dimethylglycyl)-D-gluconic acid. ... 

Pangamic acid (formerly known as vitamin Bjj, 5-135) occurs mainly in cereals, legumes, seeds (sunflower and pmnpkin seeds) and yeast. Its nutritional value is debatable andno scientific evidence exists to substantiate any physiological function or biological effects. It probably acts (like choline) as a lipotropic factor, which stimulates... 

Still under criticism and study are such compounds tis bioflavonoids, pangamic acid, and Laetrile. 

Disorders Treated with Pangamic Acid Deficiency Symptons Dosage Toxicity... 

The nutritional status and biological role(s) of pangamic acid await clarification. Its stimulation of such fundamental processes of transmethylation, cellular respiration, etc. may have physiological application. Certainly, there Is sufficient indication of the value of pangamic acid as a therapeutic agent to warrant further study. In the meantime, pangamic acid shouid not be taken unless prescribed by a physician. 

Pangamic acid (also known as vitamin B-15, calcium pangamate, and dimethylglycene) is a chemical substance of an organic nature. It is sometimes classed as a vitamin or vitaminlike substance. Obviously, however, pangamic acid does not meet the classical definition of a vitamin, which is A substance, organic in nature, necessary in the diet in small amounts to sustain life, in the absence of which... 

The FDA classifies pangamic acid as a food additive, and, therefore, subject to the regulations requiring proof that it is nontoxic. 

Pangamic acid has been widely studied and accepted in the U.S.S.R. as a necessary food factor with important physiological actions. 

The claim that pangamic acid is a B vitamin is based primarily on its presence in B-vitamin rich foods and on the broad spectrum of physiological functions attributed to it. However, it is not known whether man or other animals have the capacity to synthesize pangamic acid, and no specific disease can be attributed exclusively to a deficiency of the substance. Thus, the designation of pangamic acid as a vitamin is not accepted by most U.S. scientists. 

But the chemical composition of pangamic acid varies from brand product to brand product, and even within the same brand. This, within itself, makes the substance controversial. Some products are a mixture of sodium (or sometimes calcium) gluconate, glycine, and diisopropylamine dichloroace-tate. However, the Russians confine their product to pangamic acid, i.e., the form of vitamin B-15 in which it occurs in nature. 

Excessive amounts of pangamic acid are excreted in urine, feces, and perspiration. 

MEASUREMENT/ASSAY. The content of pangamic acid is usually expressed in milligrams (mg). 

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