Glycoprotein ligands

P-selectin EC, platelets P-selectin glycoprotein ligand-1 (PSGL-1) Sialyl-Lewis" and others... 

Fig. 1. Surface phenotype of HSPCs. Primitive HSPCs have the phenotype of c-KitThy-ll0WLin CD34+CD33 in humans, and the mouse counterparts have the phenotype of c-KifThy-llowLin Sca-l+. Primitive HSPCs express CXCR4 as the major chemokine receptor and various adhesion molecules such as VLA-4, VLA-5, LFA-1, P-selectin glycoprotein ligand-1 (PSGL-1), and CD44 for migration to the stem cell niche.

Wang K, Zhou Z, Zhou X, et al. Prevention of intimal hyperplasia with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model, J Am Coll Cardiol 2001 38 577-582,... 

Mehta, P, Cummings, R D, McEver, R P, Affinity and kinetic analysis of P-selectin binding to P-selectin glycoprotein ligand-1, J. Biol Chem., 273, 32506-32513, 1998. 

Vachino, G, Chang, X-J, Veldman, G M, Kumar, R, Sako, D, Eouser, L A, Bemdt, M C, Cumming, D A, P-selectin glycoprotein ligand-1 is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells, J. Biol Chem., 270, 21966-21974, 1995. 

Another selectin target ligand whose carbohydrate stmcture has recently been characterized is P-Selectin Glycoprotein Ligand-1 (PSGL-1) (O Fig. 18) [200]. 

Fig. 8. Distribution of selectins and their glycoprotein ligands. Reprinted with permission from Rodger P. McEver, Selectin-carbohydrate interactions during inflammation and metastasis, Glycoconjugate J.. 14 (1997) 585-591 (Ref. 208) (1997). Kluwer Academic Publishers.

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