P-selectin ligands

P-selectin plays an essential role in the initial recruitment of leukocytes. When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface. Thrombin is one trigger of endothelial-cell release of P-selectin. Ligands for P-selectin on eosinophils and neutrophils are similar they are sialylated carbohydrates, but clearly different from those reported for E-selectin. P-selectin attaches to the actin cytoskeleton through anchor proteins. 

Entry P-Selectin Ligand P-Selectin Blocking Agent Incubation Time Incubation Temperature References... 

Wein, M, Sterbinsky, S A, Bickel, C A, Schleiner, R P, Bochner, B S, Comparison of human eosinophil and neutrophil ligands for P-selectin ligands for P-selectin differ from those for E-selectin, Am. J. Respir. Cell. Mol, 12, 315-319, 1995. 

Monzavi-Karbassi B, Stanley JS, Hennings L, Jousheghany F, Artaud C, Shaaf S, Kieber-Emmons T. Chondroitin sulfate glycosaminoglycans as major P-selectin ligands on metastatic breast cancer cell lines. Int J Cancer 2007 120 1179-1191. 

Herron, M. J., Nelson, C. M., Larson, J., Snapp, K. R., Kansas, G. S., and Goodman, J. L. (2000) Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1. Science 288, 1653-1656. 

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