5-P-cholanic acid

Abrus precatorius L. Siang Si Zi (Prayer beads) (seed) 1-Abrine, precatorine, hypaphorine, cycloarternol, squalene, trigonelline, 5-P-cholanic acid.33-450 Antiemetic, expectorant, parasiticide. 

Hydrophobically modified glycol chitosan (HGC) with 5p cholanic acid has been extensively studied both in vitro and in vivo. This polymer was developed as a new Cremophor EL-free alternative carrier systems for docetaxel [74] and paclitaxel. Physical characteristics of the nanoparticules such as size, hydrophobic core, and stability depend on the degree of 5-p cholanic acid substitution. The maximum loading content of paclitaxel into HGC nanoparticles was 10 wt% and the loading efficiency was above 90% [120]. Cytotoxicity studies on MCF7 breast cancer cells showed that HGC nanoparticles were less toxic than Cremophor EL, and allowed a higher dose of paclitaxel administration. The survival rate of mice that received 50 mg/kg paclitaxel in HGC nanoparticles increased substantially compared to 20 mg/kg PTX in Cremophor EL-ethanol solutions [120]. 

Sodium taurocholate [2-(3a,7a,12a-trihydroxy-24-oxo-5-p-cholan-24-ylamino)ethanesulfonic acid sodium salt monohydrate] [145-42-6-, 312693-83-7 345909-26-4 (x H2O)] M 555.7 (monohydrate), m 168 dec (hydrate), [a] +23.9° (c 2.5, H2O), pK of acid is 1.4. The non-sulfated bile salt has been synthesised from... 

Synonyms Cholalic acid Cholalin Colalin 3,7,12-Trihydroxycholanic acid 3a,7a,12a-Trihydroxy-5-p-cholan-24-oic acid... 

Sodium desoxycholate CAS 302-95-4 EINECS/ELINCS 206-132-7 Synonyms Deoxycholate sodium Deoxycholic acid sodium salt 7-Deoxycholic acid sodium salt (3-a,5-p, 12-a)-3,12-Dihydroxy-cholan-24-oic acid monosodium salt 3-a,12-a-Dihydroxy-5-p-cholan-24-oic acid sodium salt Sodium deoxycholate Sodium deoxycholic acid... 

Methyl 12-keto-3a,7a-diacetoxy-5jS-cholanate (XXVII, 20 g) is refluxed in methanol (100 ml) with KOH (6 g/200 ml water) for 45 min till a clear solution is obtained. After the methanol is partially removed by evaporation, the solution is cooled, diluted with water (200 ml) and acidified with acetic acid. The product is 3a-hydroxy-7a-acetoxy-12-keto-5/3-cholanic acid [XXVIII, Wieland and Kapital (52)] m.p. 238-242°C yield, 87%. 

BAs are steroid compounds, hydroxyl-derivatives of 5-P-cholan-24-oic acid. BAs are the hnal products of the hepatic biotransformation of cholesterol and they are normally present in the bile as mixed micelles. They have different physicochemical properties according to the number, position, and orientation of their hydroxyl groups, and the type of conjugation with glycine and taurine, which forms the glyco- and tauro-derivatives. These factors influence their solubility, hydrophobicity, and detergent properties [35-37]. 

Uses Oil-phase ingred. for dispersing pigments used in pressed powds. ennol-lient, plasticizer, and skin conditioner in cosmetics Trihydrated alumina. See Aluminum hydroxide 1,1,3-Trihydroperfluoro-1-propanol. See 2,2,3,3-Tetrafluoro-l-propanol 3,7,12-Trihydroxycholanic acid 3a,7a,12a-Trihydroxy-5-P-cholan-24-oic acid. See Cholic acid... 

Methyl 3a-Acetoxy-6a-bromo-7a-hydroxy-5 -cholanate (XIa, Fig. 9) Methyl 3n -acetoxy-6a-bromo-7-keto-5/3-cholanate (XXXll) (2.4 g) is dissolved in methanol (200 ml) and the solution is chilled in an ice bath. Sodium borohydride (3 g) is added in small portions. The mixture is kept at ice-bath temperature for 15 min and allowed to remain at room temperature for 45 min, then acidified with acetic acid and evaporated at room temperature to a small volume. The crystalline product, methyl 3a-acetoxy-6a-bromo-7a-hydroxy-5,5-cholanate (XIa) is recrystallized from methanol m.p. 149-152°C yield, 85%. 

The crude product is dissolved in benzene-hexane (1 1) and applied to a column containing 125 g. of silicic acid (Note 10). Elution with the same solvent gives traces (less than 5 mg. each) of the two fast-moving components in fractions 2 and 4 (125-ml. fractions) and chromatographically pure cholane-24-aI in fractions 5-8 (Note 11). Evaporation of the pooled fractions yields 870 mg. (84%) of the pure crystalline aldehyde, m.p. 102-104°. Recrystallization from 5 ml. of acetone raises the melting point to 103-104° (Note 12). 

Maitra. U. Bag. B.G. Rao. P. Powell. D. Bile acids in asymmetric synthesis. 5. Asymmetric synthesis of steroidal Troger s base analogs. X-ray molecular structure of methyl 3a, 12a- 6H, 12H-5.1 I -methanodibenzo[b,f][l,5]diazo-cine-2,8-bisacetoxy -5P-cholan-24-oate. J. Chem. Soc., Perkin Trans. 1 1995, 2049-2507. 

CAS 83-44-3 EINECS/ELINCS 201-478-5 Synonyms 5p-Cholan-3a,12p-diol Cholan-24-oic acid, 3,12-dihydroxy-, (3a,5p,12a])- Choleic acid Cholerebic Cholic acid, deoxy-Cholorebic Deoxycholatic acid Deoxycholic acid 5p-Deoxycholic acid 7-Deoxycholic acid 3a,12a-Dihydroxy-5p-cholanate 3,12-Dihydroxycholanic acid 3a,12a-Dihydroxycholanic acid 3a,12a-Dihydroxy-5P-cholanoic acid L7-p-(1-Methyl-3-carboxypropyl) etiocholane-3a,12o-diol Pyrochol Septochol Empirical C24H40O4... 

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