Hydrophobically modified glycol chitosan

Hydrophobically modified glycol chitosan (HGC) with 5p cholanic acid has been extensively studied both in vitro and in vivo. This polymer was developed as a new Cremophor EL-free alternative carrier systems for docetaxel [74] and paclitaxel. Physical characteristics of the nanoparticules such as size, hydrophobic core, and stability depend on the degree of 5-p cholanic acid substitution. The maximum loading content of paclitaxel into HGC nanoparticles was 10 wt% and the loading efficiency was above 90% [120]. Cytotoxicity studies on MCF7 breast cancer cells showed that HGC nanoparticles were less toxic than Cremophor EL, and allowed a higher dose of paclitaxel administration. The survival rate of mice that received 50 mg/kg paclitaxel in HGC nanoparticles increased substantially compared to 20 mg/kg PTX in Cremophor EL-ethanol solutions [120]. [Pg.32]

Hwang HY, Kim IS et al (2008) Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles. J Control Release 128 23-31... [Pg.40]

Kim J-H, Kim Y-S et al (2006) Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel. J Control Release 111 228-234... [Pg.42]

Recently, new basal insulin formulation was designed by Jo et al. (2008). Zinc-crystallized insulin was physically loaded into hydrophobically modified glycol chitosan (HGC) nanoparticles by dialysis method (Figure 22.2). The biological activities of insulin-HGC formulations were investigated... [Pg.287]

Yoo, H. S., Lee, J. E., Chung, H., Kwon, I. C., and Jeong, S. Y. 2005. Self-assembled nanoparticles containing hydrophobically modified glycol chitosan for gene dehvery. Journal of Controlled Release 103 235-243. [Pg.369]

Self-assembled nanoparticles containing hydrophobically modified glycol chitosan For gene delivery [139]... [Pg.74]

Hydrophobically modified glycol chitosan NPs -encapsulated camptothecin For enhancing the drug stability and tumor targeting in cancer therapy [200]... [Pg.78]

Hydrophobically modified glycol chitosan NPs Cellular uptake mechemism and intracellular fate of [202]... [Pg.78]

Min KH, Park K, Kim YS, Bae SM, Lee S, Jo J et al (2008) Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumortargeting in cancer therapy. J Control Release 127 208-218... [Pg.86]

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