P-Catenin

Stein U, Arlt F, Walther W et al (2006) The metastasis-associated gene S100A4 is a novel target of p-catenin/ T-cell factor signaling in colon cancer. Gastroenterology 131 1486-1500... [Pg.1106]

Wnt/non-P-catenin signaling is not as well characterized biochemically as the Wnt/p-catenin-dependent pathway this may reflect that it is molecularly more diverse, at least in vertebrates. In Drosophila the best characterized Wnt/non-P-catenin pathway is planar cell polarity (PCP) signaling. Ironically, although it certainly depends on a Fz receptor, it remains... [Pg.1318]

LRP5 and 6 are not required for Wnt/non-(3-catenin signaling instead a protein called Ryk (derailed in Drosophila) is the best characterized coreceptor for the Fz proteins in non-(3-catenin signaling. Ryk/derailed was first implicated in axon guidance, but could conceivably play a more general role in all forms of Wnt/non-P-catenin signaling controlling cell shape, movement, and polarity. [Pg.1320]

Wnt Signaling (general) Wnt4 Sfrp Fz LRP5 Dvl GSK3 p-catenin... [Pg.1321]

Veeman MT, Axelrod ID, Moon RT (2003) A second canon functions and mechanisms of p-catenin-independent Wnt Signaling. Dev Cell 5 367-377... [Pg.1322]

Luu HH, Zhang R, Haydon RC et al (2004) Wnt/p-catenin signaling pathway as novel cancer drug targets. Cun-Cancer Drug Targets 4(8) 653-671... [Pg.1322]

Carter, O., Bailey, G.S., and Dashwood, R.H., The dietary phytochemical chlorophyllin alters E-cadherin and P-catenin expression in human colon cancer cells International Research Conference on Food, Nutrition and Cancer, J. Nutr., 134,3441S, 2004. [Pg.49]

TANKYRASE INHIBITION AS A STRATEGY FOR Wnt/p-CATENIN PATHWAY MODULATION... [Pg.240]

Actin, spectrin, tau, vimentin, P-catenin, gelsolin, kinectin... [Pg.604]

PSl forms a complex with p-catenin (CTNNBl), increasing P-catenin stability, and P-catenin levels are markedly reduced in the brains of AD patients with PSl mutations (157). One pathological characteristic of AD is extensive synapse loss. PSl is localized at the synapse, where it binds N-cadherin and modulates its adhesive activity. PSl is essential for efficient trafficking of N-cadherin from the ER to the plasma membrane. PW-mediated delivery of N-cadherin to the plasma membrane is important for N-cadherin to exert its physiological function, and it may control the state of cell-cell contact (158). [Pg.238]

PSl plays a role in P-catenin signaling and in the regulation of apoptosis. Phosphorylation of PSl is regulated by two independent signaling pathways... [Pg.243]

Keywords Hepatocyte liver progenitor cell TGF-(3 p-catenin cancer stem cell... [Pg.123]

We hypothesize that different patterns of nuclear p-catenin occur, depending on the localization of neoplastic cells in the tumor and correlating with variations in the differentiation state of malignant hepatocyte subpopulations. At the inner area of the cancerous tissue, neoplastic hepatocytes might have low or are even devoid of nuclear p-catenin and exhibit proliferation. In contrast, malignant hepatocytes that have undergone EMT at the invasive front might... [Pg.129]

Deoxycholic acid has also been demonstrated to activate other pivotal oncogenic pathways in CRC cells in vitro including p-catenin/T-cell factor-mediated transcription, extra-cellular signal-regulated kinase activation downstream of the epidermal growth factor receptor and Jun-N-terminal kinase... [Pg.90]

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