Targeting the Transcriptional Hub P-Catenin Using Stapled Peptides

Targeting the Transcriptional Hub P-Catenin Using Stapled Peptides 

Tumors form in a multistep process whereby wild-type cells evolve into transformed ones. During this process, cells acquire certain biological capabilities that have been defined as the so-called hallmarks of cancer, among which are repUcative immortality, sustained proliferation, and increased tissue invasion [1]. Acquisition of these hallmarks is inevitably achieved by activation of certain signaling pathways. Interestingly, several of the most widely usurped pathways are those that are ordinarily active in most cell types only during embryonic 

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