Rashes oxcarbazepine

Oxcarbazepine Sedation Dizziness Ataxia Nausea Rash Hyponatremia... 

The most frequently reported side effects are dizziness, nausea, headache, diarrhea, vomiting, upper respiratory tract infections, constipation, dyspepsia, ataxia, and nervousness. It generally has fewer side effects than pheny-toin, valproic add, or carbamazepine. Hyponatremia has been reported in up to 25% ofpatients and is more likely in the elderly. About 25% to 30% of patients who have had a rash with carbamazepine will have a cross-reaction with oxcarbazepine. 

Skin rash reactions to carbamazepine may resolve in 75% of patients with epilepsy when switched to oxcarbazepine thus,... 

Gastric upset from CBZ may be diminished by taking the drug after meals. Common toxicities include blurred vision, dizziness, drowsiness, and ataxia. Tremor, depression, hyponatremia, and cardiac disturbances are seen at high serum concentrations. Idiosyncratic rashes are common rarer severe idiosyncratic effects include aplastic anemia, agranulocytosis, thrombocytopenia, and jaundice. Therefore, patients receiving CBZ should have periodic blood count determinations and liver function tests. Both CBZ and oxcarbazepine can reduce plasma 25-hydroxy vitamin D levels (45). CBZ increases levels of phenytoin and decreases levels of... 

Patients with hypersensitivity reactions to carbamazepine can be expected to show cross-sensitivity (e.g., rash) or related problems to oxcarbazepine. The improved toxicity profile for oxcarbazepine when compared to CBZ may result from absence of the epoxide or CBZ-iminoquinone metabolites (47). The most common side effects are headache, dizziness, nystagmus, blurred vision, somnolence, nausea, ataxia, and fatigue. The Incidence of adverse effects has been related to elevated serum MHD concentrations (52). Adverse effects on cognitive status, hyponatremia, and serious dermatological reactions have been reported, as has hyponatremia (53). 

Maschio M, Dinapoli L, Vidiri A, Muti P. Rash in four patients with brain tumor-related epilepsy in monotherapy with oxcarbazepine, during radiotherapy. J Neurol 2010 257(11) 1939-40. 

In a retrospective study of the medical records of 26 children and adolescents with epilepsy who had been rapidly switched from carbamazepine to oxcarbazepine (dose conversion ratios 1.0-1.5), the transition was well tolerated three patients had adverse events (rashes) 21T],... 

A 53-year-old man, who was taking enalapril maleate, amlodipine besylate, and aspirin, had several seizures and was given first pheno-barbital, then valproic acid, and then oxcarbazepine. After 20 days he developed a generalized skin rash and oral ulceration followed by a high fever. He had widespread confluent erythematous macules and papules and numerous flat atypical target lesions with central dusky discoloration on the face, neck, trunk, and proximal arms. Genotyping showed the presence of an HLA-B 1502 allele. 

A 13-year-old boy developed a severe rash and systemic symptoms after starting to take oxcarbazepine [225" ]. 

Skin A 2-year-old girl with a complicated medical history developed SJS 9 days after starting levetiracetam. She had previously developed a rash to oxcarbazepine. This is the first report of levetiracetam-induced SJS in a child [105 ]. 

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