Amlodipine besylate

Tablets 5 mg amlodipine besylate/10 mg atorvastatin calcium (as base), 5 mg amlodipine besylate/20 mg atorvastatin calcium (as base), 5 mg amlodipine besylate/40 mg atorvastatin calcium (as base), 5 mg amlodipine besylate/80 mg atorvastatin calcium (as base), 10 mg amlodipine besylate/10 mg atorvastatin calcium (as base), 10 mg amlodipine besylate/20 mg atorvastatin calcium (as base), 10 mg amlodipine besylate/40 mg atorvastatin calcium (as base), 10 mg amlodipine besylate/80 mg atorvastatin calcium (as base) Rx)...

Calcium channel blockers amlodipine besylate diltiazem hydrochloride nifedipine... 

After oral administration of S-amlodipine besylate, bioavailability is 65-80%. Approximately 93% drug is bound to plasma proteins. It is extensively converted to inactive metabolites via hepatic metabolism. It is excreted in urine as 10% parent drug and 60% of the metabolites. 

R. Sahu, V.B. Patel, Simultaneous spectrophotometric determination of amlodipine besylate and atorvastatin calcium in binary mixture, Indian J. Pharm. Sci. 69 (2007) 110-111. 

The product of Step 2 was also used in the Hantzsch condensation to prepare phthaloyl amlodipine, a precursor for amlodipine besylate (3). 

A. Abdoh, M. M. Al-Omari, A. A. Badwan, A. M. Y. Jaber, Amlodipine besylate— excipients interactions in solid dosage form, Pharm. Dev. Technol. 9 (2004), 15-24. 

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