Oxantel

Albendazole Bromoxanide Bunamidine Cambedazole Clioxanide Cyclobendazole Flubendazole Lobendazole Antihistaminics Mebendazole Niclosamide Nitramisole Nitrodan Oxantel Oxfendazole Oxibendazole Thenium Closylate... 

OzTaetoprim, 302 Oxawniquine, 372 Oxantel, 303 Oxaprozin, 263 Oxazepam, 402 Oxazole synthesis, 263 Oxazolinone synthesis,... 

Pyrantel pamoate is a broad-spectrum antihelminthic highly effective for the treatment of pinworm, ascaris, and Trichostrongylus orientalis infections. It is moderately effective against both species of hookworm. It is not effective in trichuriasis or strongyloidiasis. Oxantel pamoate, an analog of pyrantel not available in the USA, has been used successfully in the treatment of trichuriasis the two drugs have been combined for their broad-spectrum antihelminthic activity. 

Oxantel pamoate (Quantrel) oxantel/pyrantel pamoate (Telopar)... 

Oral tablets containing 100 mg (base) of each drug suspensions containing 20 or 50 mg (base) per mL Note Oxantel pamoate and oxantel/pyrantel pamoate are not available in the USA. 

Trichuris trichiura (whipworm) Mebendazole or albendazole1 Oxantel/pyrantel pamoate2... 

Oral 250 mg capsules outside the USA, 50 mg/mL syrup Oxantel pamoate (Quantrel) oxantel/pyrantel pamoate (Telopar)... 

Note Oxantel pamoate and oxantel/pyrantel pamoate are not available in the USA. 

Whipworm infection Tridiuris trichiura Dichlorovos, thiabendazole mebendazole, oxantel... 

The structure of 3, however, provided a useful lead to follow. This led to the synthesis of 2-[2-(2-thienyl)ethyl]-2-imidazoline (8) having activity against different roundworms in mice and sheep [1]. Compound 8 was synthesized by the reaction sequence shown in scheme 2. Soon a series of compounds of type 9 [4-6] were prepared of which pyrantel (10a), morantel (10b) and oxantel (11) showed high anthelmintic activity. 

A simpler large scale method to obtain pyrantel, morantel (10a,b) and oxantel (11) involves condensation of 23 with an aryl aldehyde in presence of a base. Water is removed by azeotropic distillation or by using a chemical scavenger like methyl/ethyl formate, which reacts with water to push the reaction in the forward direction (Scheme 3). Other methods to prepare pyrantel and its derivatives are also reported [5,6,13-17]. The l-(2-arylvinyl)pyridium salts (18,19), structural congeners of pyrantel/moratel, are prepared by quaternisation of pyridine with the appropriate bromomethylaryl ketones (27) to afford 28. The latter is reduced with sodium boro-hydride to give the carbinol 29, which on dehydration leads to the formation of l-(2-arylvinyl)pyridinium bromides (18,19) [8]. 

Of a number of tetrahydropyrimidines synthesized as possible anthelmintic agents, three drugs namely pyrantel (10a), morantel (10b) and oxantel (11) emerged as effective agents for treating intestinal nematode infections in humans and domestic animals [18-25]. 

Oxantel may also be used to treat ascariasis, enterobiasis, hookworm infections and trichuriasis if given in combination with pyrantel pamoate or levamisole [18,23]. Thus, a combination of pyrantel pamoate (5 mg/kg) and oxantel pamoate (5 mg/kg) given on two consecutive days produced 94% reduction in egg output in a large number of Chinese patients infected with Ascaris, whipworms and hookworms [34]. Like pyrantel pamoate, oxantel is also well tolerated producing only mild and transient side effects [18]. 

Pamoate, C H NjOg. CP 14445-16, oxantel embonate, Telopar. Mixture with pyrantel pamoate (1 1), Quantrel. therap cat Anthelmintic (Nematodes). therap cat (VET) Anthelmintic (Nematodes). 

CP 14,445-16 EINECS 272-332-6 Oxanel pamoate Oxantel ebonate Telopar. Anthelmintic. Targets nematodes. Pfizer Inc. 

Pyrantel is a depolarizing neuromuscular blocking agent that opens nonselective cation channels and induces marked, persistent activation of nicotinic acetylcholine receptors, which results in spastic paralysis of the worm. Pyrantel is effective against hookworm, pinworm, and roundworm unlike its analog oxantel, it is ineffective against Trichuris trichiura. 

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