Drugs suspensions

JW Mauger, SA Howard, K Amin. Dissolution profiles for finely divided drug suspensions. J Pharm Sci 72(2) 190 193, 1983. 

NB Shah, BB Sheth. Effect of polymers on dissolution from drug suspensions. J Pharm Sci 65(11) 1618 1623, 1976. 

M. Ruff, D. Schotik, J. Bass, and J. Vincent, Antimicrobial drug suspensions a blind comparison of taste of fourteen common pediatric drugs, Pediatr. Infect. Dis. J., 10, 30 (1991). 

Oral tablets containing 100 mg (base) of each drug suspensions containing 20 or 50 mg (base) per mL Note Oxantel pamoate and oxantel/pyrantel pamoate are not available in the USA. 

Residual Losses and Yields. The yield of the concentrate, filling, and any residual tank or pumping loss is an important measure of how the process behaved. Accounting for drug suspension and solution should be complete and rigorously done. An investigation of losses should be made when these losses exceed unusual amounts (about 5-7%) of the drug suspension or solution. Tentative specifications of the yield should be considered after the validation batches and reviewed after several more production batches are made. 

Withdrawal of approval of an abbreviated new drug application under section 505(j)(5) of the act Notice of withdrawal of approval of an application or abbreviated application for a new drug Suspension of approval of an abbreviated new drug application... 

Ziller, K.H. Rupprecht, H. Control of crystal growth in drug suspensions 1. Design of a control unit and application to acetaminophen suspensions. Drug Dev. Ind. Pharm. 1988, 14, 2341-2370. 

Fig. 11 Comparison of nanoemulsion Softgel to a drug suspension capsule.

Physical Stability of Drug Suspension. The physical stability of the non-polar drug suspensions formulated in pMDIs again depends on many parameters, such as propellant type, chemical properties of the drug compounds, and the surfactants used in the formulation. A suspension is a liquid system in which insoluble solid particles are dispersed in a liquid medium. Suspensions can be divided into colloidal suspensions, in which the... 

Atmospheric conditions Drug suspension concentration Drug suspension Filled canisters Gross leakage and safety... 

A reaction like lupus pernio, with purple discoloration, swelling, red papules, and desquamation of the distal parts of several toes, which resolved after drug suspension and recurred after resumption, has been observed (42), as have subcutaneous fat necrosis (SEDA-11, 92), and fixed drug reaction (SEDA-12, 84). 

Nebulizers are designed primarily for use with aqueous solutions or suspensions. Typically the drug suspensions use primary particules in the range of 2-5 microns. As a consequence, pharmaceutical solution technology, consistent with that used for parenteral products, may be applied to nebulizer solution or suspension formulation and processing. 

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