Ornithine decarboxylase and

Yarbrough JD, Grimley JM, Karl PI. 1986b. Relationship of ornithine decarboxylase and thymidine kinase to mirex-induced liver growth. Am J Physiol 251 G859-G865. 

Endo Y Simultaneous induction of histidine and ornithine decarboxylases and changes in their product amines following the injection of Escherichia coli lipopolysaccharide into mice. Biochem Pharmacol 1982 31 1643-1647. 

Ask A, Persson L, Rehnholm A, Frostesjo L, Holm I, Heby O (1993) Development of resistance to hydroxyurea during treatment of human myelogenous leukemia K562 cells with alpha-difluoromethylornithine as a result of coamplification of genes for ornithine decarboxylase and ribonucleotide reductase R2 subunit. Cancer Res 53 5262-5268... 

Eflorni thine Inhibits ornithine decarboxylase and biosynthesis of polyamines Affects cell division, differentiation... 

Bhide. Effects of tobacco-specific nitrosamines and snuff extract on cell proliferation and activities of ornithine decarboxylase and aryl hydrocarbon hydroxylase in mouse tongue primary epithelial cell cultures. J Cancer Res Clin Oncol 1989 115(6) 558-563. 

It is an inhibitor of ornithine decarboxylase and is used as second line therapy for advanced CNS African trypanosomiasis. After oral or IV administration, peak plasma level is reached rapidly and elimination half life is approximately three hours. 

Furihata, C., Hatta, A. Matsushima, T. (1989) Inductions of ornithine decarboxylase and replicative DNA synthesis but not DNA single strand scission or unscheduled DNA synthesis in the pyloric mucosa of rat stomach by catechol. Jpn. J. Cancer Res., 80. 1052-1057... 

Ornithine Decarboxylase and Polyamines in Neurotoxicity Mediated by Glutamate... 

Haemonchus contortus cloning and functional expression of a cDNA encoding ornithine decarboxylase and development of a screen for inhibitors. Exp Parasitol 87 171-184, 1997. 

IMANISHI, S., HASHIZUME, K., NAKAKITA, M., KOJIMA, H MATSUBAYASHI, Y., HASHIMOTO, T., SAKAGAMI, Y., YAMADA, Y NAKAMURA, K., Differential induction by methyl jasmonate of genes encoding ornithine decarboxylase and other enzymes involved in nicotine biosynthesis in tobacco cell cultures. Plant Mol. Biol., 1998,38,1101-1111. 

The concept of inhibition via p elimination of fluoride ion has now been extended to the irreversible inhibition of a-amino acid decarboxylases. Ornithine decarboxylase (ODC), which catalyzes the decarboxylation of ornithine to putrescine is irreversibly inhibited by a-difluoromethylornithine (IX Fig. 9) (28). In this case, the carbanion formation which precedes P elimination is generated by loss of CO2, and not by proton abstraction (Fig. 9). Similarly, aromatic amino acid decarboxylase is irreversibly inhibited by C-difluoromethyl-3,4-dihydroxyphenylalanine (29) while histidine decarboxylase, ornithine decarboxylase and aromatic amino acid decarboxylase have been inhibited by the corresponding <=d-monof luoromethylanri.no acids, respectively (29). 

Wei, H., Tye, L., Bresnick, E., and Birt, D.R, Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice, Cancer Res., 50, 499-502, 1990. 

Recidivation is generally due to undetected small intra-hepatic foci. Especially in cirrhosis, the recurrence rate is very high as a result of this factor. A further cause of recidivation after primary RO resection is attributed to the multicentricity of the HCC, i. e. synchronic or metachronic development of additional tumours which are independent of the primary tumour. Therefore, the secondary prophylaxis takes on a special meaning (systemic or intra-arterial chemotherapy, interferon, retinoids, autologous lymphocyte transfusion, etc.). An increase in ornithine decarboxylase and spermidine is apparently a high risk factor for recurrence. Even after recidivation, repeated resection or interventional procedures (e.g. RFTA) are sometimes successful. 

Furihata C, Yamakoshi A, Matsushima T. 1988. Inductions of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by formaldehyde. Jpn J Cancer Res 79 917-920. 

Our microarray data set contains substantial information about the mechanism and extent of CS effects on various genes. The small number of distinct temporal patterns indicates that a limited number of mechanisms may mediate CS pharma-cogenomics. Of special note, several genes such as ornithine decarboxylase and hydroxysteroid sulfotransferase were represented by multiple different probes on the gene arrays. Reasonable concordance in prohles and dynamic parameters from multiple probes indicated a good degree of reproducibility in results. 

Ciubotariu, D., Grozav, A., Gogonea, V., Ciubotariu, C., Medeleanu, M., Dragos, D., Pasere, M. and Simon, Z. (2001) The effects of retinoids upon epithelial differentiation of hamster trachea, induction of ornithine decarboxylase and promotion of tumors in mouse epidermis. A QSAR study by MTD method. MATCH Commun. Math. Comput. Chem., 44, 65-92. 

Mikol, Y. B. and Poirier, L. A., An inverse correlation between hepatic ornithine decarboxylase and S-adenosylmethionine in rats, Cancer Lett., 13, 195, 1981. 

The use of suicide inhibitors of ornithine decarboxylase and arginine decarboxylase, coupled with the efficiency of incorporation of labelled precursors, led to the conclusion that arginine decarboxylase was the source of putrescine for tobacco alkaloids including 1 and 2 [46], Labelled spermidine was incorporated into 1 and 2, apparently via degradation to putrescine [47]. In vitro properties of the nicotine demethylase activity from Nicotiana otophora were characterized [59]. 

Bateman, 1994). Coleman and colleagues (1994) have documented rapid exchange between subunits of dimeric ornithine decarboxylase and suggest that this exchange facilitates regulation by antizyme. In contrast, there is no evidence for a rapid equilibrium between subunits of the 14-subunit chaperone GroEL (A. Horwich, personal communication), or in a number of other multisubunit enzymes (Distefano et al., 1990 Perry et al., 1992 Wente and Schachman, 1987). The potential importance of subunit exchange to sHsp function is discussed further below. 

Otten, U., Hatanaka, H. and Thoenen, H. (1978) Effect of NGF on general growth and differentiation of sympathetic neurons induction of ornithine decarboxylase and tyrosine hydroxylase as respective examples. In E. Usdin, I.J. Kopin and J. Barchas (Eds.), 4th International Catecholamine Symposium, Pacific Grove, CA, 1978, Pergamon Press, New York, pp. 115-117. 

Ornithine decarboxylase and polyamine M. racemosus Initial 30-50-fold increase in activity of ODC throughout yeast to hyphal transition 123... 

There is some evidence to suggest that soluble compounds produced by lactic acid bacteria may act directly on tumor cells to inhibit their growth. Arimochi et al. (1997) showed (a) an inhibitory effect of L. acidophilus on azoxymethane-induced ACF formation in rat colon and (b) enhanced removal of 0 -methylguanine from the colonic mucosal DNA. This inhibitory effect was found in culture supernatants and not from bacterial cells. Furthermore, other studies have shown that dietary administration of lyophilized cultures of B. longum suppressed azoxymethane-induced colonic tumor development, along with a decrease in colonic mucosal cell proliferation and colonic mucosal and tumor ornithine decarboxylase and ras-p21 activities (Reddy, 1998). 

Hanfrey, C. Sommer, S. Mayer, M.J. Burtin, D. Michael, AJ. (2001). Arabidopsis polyamine biosynthesis absence of ornithine decarboxylase and the mechanism of arginine decarboxylase activity. The Plant Journal, Vol. 27, No. 6, p>p 551-560, ISSN... 

Brecka, H., M. Birecki, and M. W. Frohlich, Arginine and ornithine decarboxylases and polyamines in pyrrolizidine alkaloid-containing plants. Abstracts, Phytochem. Soc. North America, Annual Meeting, 1988. 

The Regulation and Function of Ornithine Decarboxylase and of the Polyamines E. S. Canellakis, D. Viceps-Madore,... 

F. Wu, P. Christen, and H. Gehring. A novel approach to inhibit intracellular vitamin B 6-dependent enzymes Proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase. FASEB Journal 25 2109-2122 (2011). 

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