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Organic synthesis illustrating reactions available

With a range of methods available for the formation of 1,3-dicarbonyl compounds, the dicarbonyl diazomethanes can be readily prepared via a simple diazo transfer reaction with sulfonyl azide. This has made a vast array of dicarbonyl diazomethanes available, which enhances the versatility in organic synthesis. A selection of examples from recent literature to illustrate the versatility of the cyclopropanation using dicarbonyl diazomethane in the construction of natural products as well as other biologically active compounds is described below. [Pg.677]

This short text is intended to introduce the student of synthetic organic chemistry to the reactions of organoboron and organosilicon compounds which have been exploited by organic chemists, and to illustrate how these reactions have been applied to problems in organic synthesis. It is hoped that the chemistry described in this slim volume will encourage students to consult the more comprehensive reference texts and reviews available. These are listed in the bibliographies at the end of each section. [Pg.95]

Regarding acylation reactions, acylation of alcohols produces esters and acylation of amines produces amides Both of these transformations are illustrated in Figure 8.2. These, in addition to the introduction of acyl groups adjacent to carbonyls (Scheme 8.11), only hint at the breadth of related acylation reactions available and useful in organic synthesis. One additional reaction is the Friedel-Crafts acylation illustrated in Scheme 8.12. Through this transformation, extended functionalization of aryl groups becomes accessible. [Pg.141]

The electron-donating nature of this diene confers high reactivity and orientational specificity in its reaction with unsymmetrical dienophiles.5 This fact, coupled with the readily available conversion to the a,(3-un-saturated ketone from the imparted functionality, makes l-methoxy-3-trimethylsiloxy-1,3-butadiene (2) a potentially very valuable reagent in organic synthesis. The general reaction scheme is illustrated below ... [Pg.76]

The Diels-Alder reaction is one of the most powerful carbon-carbon bond forming processes in organic synthesis [69]. Considerable experimental work has been carried out to improve the rate as well as the selectivity of Diels-Alder reactions [69]. Theoretical work in understanding this important reaction is relatively small compared to the huge amount of available experimental data (see references in Ref. 17). As a result, the Diels-Alder reaction is well studied, but not completely understood. From our research efforts accumulated over the last few years, we summarize the differences discovered between the computed transition structures of the Diels-Alder reaction in vacuum, microsolvated environments, and fully solvated systems for one of the simplest Diels-Alder reactions, acrolein, and s-cis butadiene, as schematically illustrated in Fig. 4. Molecular origins leading to the rate enhancement and selectivities are discussed, and then are related to the issues surrounding enzymatic catalysis. [Pg.334]

There is a vast literature on the chemistry of ferrocene, but very little use has been made of this substance in organic synthesis. As ferrocene is readily available (Jolly, 1968) and undergoes a great variety of reactions such as acylation, alkylation, sulfonation, and metalation (Perevalova and Nikitina, 1972), a simple means of removing the iron at the end of the reaction sequence would provide a ready route to substituted cyclopentane derivatives. Some typical acylation reactions [which take place 3.3 x 10 times faster than with benzene (Rosenblum et al., 1963b) are illustrated in Eqs. (64) (Hauser and Lindsay, 1957), (65) (Rosenblum and Woodward, 1958), and (66) (Rosenblum et al., 1963a). [Pg.27]

The wide variety of coupling methods adapted from organic synthesis to condensation polymerization of just one CP can be appreciated from Fig. 5-12. for poly(pheny-lene). Typical condensations and eliminations adapted to syntheses of such CPs as poly(phenylene) and poly(phenylene vinylene) (P(PV)) are illustrated in Fig. 5-13. Fig. 5-14 shows the variety of precursor routes available to P(PV). More recently, the Yu group [86] has demonstrated application of Pd-catalyzed Stille and Heck reactions to the synthesis of poly(thiophene) (P(T)) derivatives (cf. Fig. 5-15. Besides the Grignard couplings such as shown in Eq. 1.6, Chapter 1, P(T) s can also be prepared via a variety of other procedures, such as Friedel-Crafts alkylation [87], and direct oxidation with FeClj as for P(Py) above. [Pg.119]

Volume 75 concludes with six procedures for the preparation of valuable building blocks. The first, 6,7-DIHYDROCYCLOPENTA-l,3-DIOXIN-5(4H)-ONE, serves as an effective /3-keto vinyl cation equivalent when subjected to reductive and alkylative 1,3-carbonyl transpositions. 3-CYCLOPENTENE-l-CARBOXYLIC ACID, the second procedure in this series, is prepared via the reaction of dimethyl malonate and cis-l,4-dichloro-2-butene, followed by hydrolysis and decarboxylation. The use of tetrahaloarenes as diaryne equivalents for the potential construction of molecular belts, collars, and strips is demonstrated with the preparation of anti- and syn-l,4,5,8-TETRAHYDROANTHRACENE 1,4 5,8-DIEPOXIDES. Also of potential interest to the organic materials community is 8,8-DICYANOHEPTAFULVENE, prepared by the condensation of cycloheptatrienylium tetrafluoroborate with bromomalononitrile. The preparation of 2-PHENYL-l-PYRROLINE, an important heterocycle for the synthesis of a variety of alkaloids and pyrroloisoquinoline antidepressants, illustrates the utility of the inexpensive N-vinylpyrrolidin-2-one as an effective 3-aminopropyl carbanion equivalent. The final preparation in Volume 75, cis-4a(S), 8a(R)-PERHYDRO-6(2H)-ISOQUINOLINONES, il lustrates the conversion of quinine via oxidative degradation to meroquinene esters that are subsequently cyclized to N-acylated cis-perhydroisoquinolones and as such represent attractive building blocks now readily available in the pool of chiral substrates. [Pg.140]

The wide availability of various polysaccharides provides an important source of some of the monosaccharides. Such monosaccharides are now used in organic reactions as low-cost starting materials in the synthesis of a range of simpler optically pure compounds (e.g. Expt 5.77). These synthetic strategies have been made possible from earlier work on the development of numerous selective protection methods, on the application of new selective reagents for functional group modification within the monosaccharide molecule, and on the realisation of the role of conformation in the interpretation of a reaction course. The preparative examples in this section are illustrative of these developments. [Pg.637]

Special iodonium salts. A range of o-trimethylsilyl-phenyliodonioarenes [111] and heteroarenes [112] as well as some similar Wc-compounds coming from norbornadiene [113] and o-carborane [114] have been obtained from the corresponding bis trimethylsilyl precursors upon reaction with one equivalent of (diacetoxyiodo)benzene. These compounds are useful for their facile in situ conversion into benzyne-type intermediates for benzyne itself the whole procedure is available in Organic Syntheses [115]. A recent improvement involved the synthesis of a new benzyne precursor illustrated in Scheme 38 [116]. [Pg.87]

These studies, and their long history, have provided numerous aspects of organic and polymer chemistry in which a variety of transition metal complexes and salts actually behave as efficient catalysts. In particular, certain ruthenium complexes, of which typical examples are illustrated in Figure 13.1, sometimes show distinctly different activity and/or selectivity from those available with other catalysts. The purpose of this chapter is to describe special features of ruthenium catalysts in these radical reactions, and to highlight the importance of ruthenium-catalyzed radical reactions in organic and polymer synthesis. [Pg.334]


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Illustrative Reactions

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