Oral powders

Viracept tabs, 50 mg/g oral powder 750 mg tid with hepatic impairment snack hyperglycemia fat maldistribution increased bleeding in hemophiliacs LFT elevation and substrate... 

Oral powders Appearance, color, odor, and moisture... 

Oral powder- The oral powder may be mixed with a small amount of water, milk, formula, soy formula, soy milk, or dietary supplement once mixed, the entire contents must be consumed in order to obtain the full dose. Acidic food or juice (eg, orange juice, apple juice, or apple sauce) are not recommended because of bitter taste. Do not reconstitute with water in its original container. Once mixed, store the oral powder for no more than 6 hours. May be refrigerated for up to 6 hours. 

Phenylketonurics Nelfinavir oral powder contains 11.2 mg phenylalanine per g of powder. 

Oral Powder for oral solution, makes 2L or 4L Senna (Senokot, Ex Lax, others)... 

Low topical solutions and topical powders oral tablets and oral suspensions topical oral powders (hard and soft and lingual aerosols gelatin), capsules, oral solutions, and suspensions... 

The most common solid oral dosage forms are capsules and tablets. For the purpose of this guidance, oral powders and granules for reconstitution are also included in this group. 

Oral powder for 100 mg/5 mL oral solution Paromomycin (Humatin)... 

Oral 500, 625 mg tablets 500 mg chewable tablets Polyethylene glycol electrolyte solution (CoLyte, GoLYTELY, others) Oral Powder for oral solution, makes one gallon (approximately 4 L) Psyllium (generic, Serutan, Metamucil, others)... 

Oral Powders Appearance, color, odor, moisture content of powder, and, if intended for reconstitution, appearance, pH, and dispersibility/dissolution properties. 

Some sterile powder formulations (these are predominantly, but not exclusively, antibiotics) may require sampling, mixing, milling, and subdivision activities similar to those found in oral powder manufacturing. The facilities and equipment utilized for these products is substantially different from that used for liquids, and the production area bears little resemblance to that utilized for liquids. These materials are received sterile and must be processed through sterilized equipment specifically intended for powder handling in a fully aseptic environment with ISO 5 protection over all open container activities. 

The most common glass-packed solid oral dosage forms are oral powders and granules for reconstitution. A typical solid oral dosage form container closure system is a glass bottle (although plastic bottles are also used) with a screw-on or snap-off closure. A typical closure consists of a metal cap, often with a liner and frequently with an inner seal. 

Thoma K, Kerker R. Photoinstabilitat von Arzneimitteln. 3. Mitteilung Photoinstabil-itat und Stabilisierung von Nifedipin in Arzneiformen. Pharm Ind 1992 54 359-365. Helin MM, Kontra KM, Naaranlahti TJ, Wallenius KJ. Content uniformity and stability of nifedipine in extemporaneously compounded oral powders. Am J Health-Syst Pharm 1998 55 1299-1301. 

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Guide (oral powder for reconstitution, buccal patch, granules, film-coated, and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Ganadian List of Acceptable Non-medicinal Ingredients. 

C2oHi7F2N303 HCI Antibacterial agent Oral Powder Injection (Embryonated broiler eggs, Chicken, Turkey) 91296-87-6 Aug. 1995/ Abbott Laboratories... 

Ivermectin Organophosphate Haloxon Dichlorvos Mites, horse bots Horse bots Oral paste Oral powder (horses) Oral gel (foals) ... 

The Committee adopted, in principle, the general monograph on oral powders and noted that it would be circulated for further comments. 

Many oral solutions are intended for pediatric administration, of which oral solution formulations are a subset of a larger choice of formulation type such as suspension, syrup, powder or microcapsules for constitution to a suspension, powder for reconstitution to a solution or suspension, solid particles (powder, coated particles, extended release, enteric-coated granules, beads) in packets or capsules to be sprinkled on food, oral powders, and chewable tablets. The broader topic of pediatric formulation development is beyond the scope of this chapter, but this chapter will cover selected oral solutions for pediatric administration. 

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