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Ophthalmic preparations design

The most common form of neomycin administration is topical. The dmg is available in combination with other antibiotics and steroids in numerous ophthalmic, otic, and dermatologic preparations designed to treat a rariety of skin and mucous membrane infections (seeTables 11-6 and 11-7). Topical ocular application of neomycin can result in... [Pg.188]

In contrast, parenteral suspensions have relatively low solids contents, usually between 0.5 and 5%, with the exception of insoluble forms of penicillin in which concentrations of the antibiotic may exceed 30%. These sterile preparations are designed for intramuscular, intradermal, intralesional, intraarticular, or subcutaneous injection. Syringeability is an important factor to be taken into consideration with injectable dosage forms. The viscosity of a parenteral suspension should be sufficiently low to facilitate injection. Common suspending vehicles include preserved isotonic saline solution or a parenterally acceptable vegetable oil. Ophthalmic and optic suspensions that are instilled into the eye/ear must also be prepared in a sterile manner. The vehicles are essentially isotonic and aqueous in composition. The reader should refer to Chapter 12 for further discussion on parenteral products. [Pg.264]

One of the important requirements of any packaging material is that it should not release any component into the drug product. Preparation of containers free of any leachables such as monomeric component is especially important for the containers of ophthalmics, parenteral products, and any liquid products. It was shown that di(2-ethylhexyl) phthalate was released from the PVC bags and that caused haziness of the taxol solution (37), USP/NF offers the protocol of chemical, spectral, and water vapor permeation tests and tolerances for plastic containers (55). Among those, chemical test is designed to give a quantitative assessment of the extractable materials in both organic solvents and water. [Pg.13]

Ophthalmic inserts are sterile, solid or semisolid preparations of suitable size and shape, designed to be inserted in the conjunctival sac, to produce an ocular effect. They generally consist of a reservoir of active substances embedded in a matrix or bounded by a rate-controlling membrane. The active substance, which is more or less soluble in the lachrymal liquid, is released over a determined period of time. Ophthalmic inserts are individually distributed into sterile containers. [Pg.165]


See other pages where Ophthalmic preparations design is mentioned: [Pg.426]    [Pg.28]    [Pg.3941]    [Pg.114]    [Pg.584]    [Pg.356]    [Pg.431]    [Pg.453]    [Pg.1116]    [Pg.446]    [Pg.103]    [Pg.1347]    [Pg.968]    [Pg.2528]    [Pg.539]    [Pg.151]    [Pg.472]    [Pg.424]    [Pg.413]    [Pg.413]    [Pg.471]    [Pg.485]    [Pg.160]    [Pg.978]   
See also in sourсe #XX -- [ Pg.417 ]

See also in sourсe #XX -- [ Pg.331 ]




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Ophthalmic preparations

Ophthalmics

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