Olfactory ensheathing cell

Ramer LM, Au E, Richter MW, Liu J, Tetzlaff W, Roskams AJ (2004) Peripheral olfactory ensheathing cells reduce scar and cavity fonnadon and promote regeneradon after spinal cord injury. J Comp Neui-ol 473 1-15. 

Other cell sources have therefore been explored as alternatives. They include olfactory ensheathing cells, embryonic stem cells, mesenchymal stem cells [6,114], and even cell lines such as the immortalized SCTM41 Schwann cells [115]. Genetic modification has been considered for implanting cells as a constant source of growth factors. Most often, fibroblasts have been engineered with this intention, e.g., to produce neurotrophins, CNTF and FGF-2 [116, 117]. 

Toshio Imaizumi, Karen L. Lankford, Willis V. Bmton, William L. Fodor and Jeffery D. Kocsis, Xeno-transplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord. Nature Biotechnology, 18 (2000), 949-953. 

Li, Y., Field, P.M., and Raisman, G., Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Science 277,2000-2002,1997. 

Imaizumi, T., Lankford, K.L., Waxman, S.G., Greer, C.A., and Kocsis, J.D., Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord, /. Neurosci. 18, 6176-6185,1998. 

Cell transplantation therapies examined for SCI repair include the use of olfactory ensheathing cells, Schwann cells, neural and embryonic stem cells, as described in the next several sections. 

Barnett, SC and Riddell, JS. 2004. Olfactory ensheathing cells (OECs) and the treatment of CNS injury Advantages and possible caveats. / Anat 204 57-67. 

Franklin, RJM. 2003. Remyelination by transplanted olfactory ensheathing cells. Anatow Record271B 71-76. 

Kalincik, T, Choi, EA, F on, F, Bianco, J, Sutharsan, R, Hayward, I, Mackay-Sim, A, Carrive, P, and Waite, PM. 2010. Olfactory ensheathing cells reduce duration of autonomic dysreflexia in rats with high spinal cord injury. Autonom Neurosci 154(l-2) 20-29. 

Pastrana, E, Moreno-Flores, MT, Avila, J et al. 2007. BDNF production by olfactory ensheathing cells contributes to axonal regeneration of cultured adult CNS neurons. Neurochem Int 50(3) 491-498. 

Shi, X, Kang, Y, Hu, Q, Chen, C, Yang, L, Wang, K, Chen, L, Huang, H, and Zhou, C. 2010. A long-term observation of olfactory ensheathing cells transplantation to repair white matter and functional recovery in a focal ischemia model in rat. Brain Res 1317 257-267. 

Srivastava, N, Seth, K, Khanna, VK, Ansari, RW, and Agrawal, AK. 2009. Long-term functional restoration by neural progenitor cell transplantation in rat model of cognitive dysfunction Co-transplantation with olfactory ensheathing cells for neurotrophic factor support. Int J Dev Neurosci 27(1) 103-110. 

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