Cell transplantation therapy

The culture module greatly facilitated homogeneous distribution of seeded cells and cultivation of a large number of cells under identical conditions. In addition, the module required a smaller volume of medium than standard cell culture systems. Importantly, this modular system provides the great advantages of scalability and safety because cell processing can be performed in a closed system. Thus, the modules facilitate the production of cells that are safe for use in cell transplantation therapies. 

Wliich is not a complication for embryonic or fetal stem cell transplant therapy ... 

Cell transplantation therapies examined for SCI repair include the use of olfactory ensheathing cells, Schwann cells, neural and embryonic stem cells, as described in the next several sections. 

Wright, KT, Masri, WE, Osman, A et al. 2008. The cell culture expansion of bone marrow stromal cells from humans with spinal cord injury Implications for future cell transplantation therapy. Spinal Cord 46(12) 811-7. 

HF due to ischemic heart disease is one of the leading causes of worldwide mortality. While current clinical therapies can improve hemodynamics in HF, currently there is no viable option for replacing damaged cardiac muscle cells. Stem cell transplantation therapy offers tremendous potential to regenerate the myocardium and improve overall quality of life. However, there are several critical challenges with stem cell transplantation such as poor cell retention at the site of transplantation, survival, and eventual functional integration into the diseased tissue. Various natural and synthetic biomaterials have been explored to enhance cell retention and survival in the ischemic myocardium, and ultimately... 

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