Oleic acid inhibitory actions

On the other hand, the inhibitory actions of oleic acid on metastasis in the liver and metastatic tumor growth in the liver, cannot be explained by the effects of DNA synthesis in LLC cells, and microvascular endothelial cells, or the adherence of LLC cells to the microvascular endothelium rather, these inhibitory actions by oleic acid are partly attributable to the inhibition of the angiogenesis induced by tumors. In conclusion, it seems likely that the antitumor and antimetastatic activities of carp oil may be partly ascribed to a fatty acid, oleic acid, as an active substance. However, the antitumor and antimetastatic effects of carp oil are insufficiently by themselves to explain the action of oleic acid. Further work is in progress to identify the active substance(s) in carp oil. 

Several chemical and epidemiological studies confirmed that olive oil s beneficial effects are related to high concentration of oleic acid and the presence of vitamin and non-vitamin antioxidants, such as DPE. This compound shows different biological actions one of them is the inhibitory effect on peroxynitrite dependent DNA base modification and tyrosine nitration. Furthermore, DPE counteracts cytotoxicity, caused by reactive oxygen species, ROS, in Caco-2 cells and in erythrocytes [70]. In particular, the Caco-2 cells imitate, in vitro, the food-intestinal tract interaction. 

In addition to blocking the demethylation of 24-methylene dihydrolanosterol at C-14, there are several other alterations of lipid metabolism in fungi treated with C-14 demethylase inhibitors. These include 1) an increase in free fatty acids, linoleic acid, and in some cases major saturated fatty acids, and 2) a decrease in oleic acid (8,22,38,39,42,47,48). The increase in free fatty acids has been attriilTted To" an imbalance between the synthesis and degradation of acyl lipids (36), and appears to be associated with changes in sterol content ra tFTer than an alternate action of the inhibitors since it also occurs in a mutant of l. maydis deficient in C-14 demethylase (46). This increase seems to occur subsequent to detectable changes in sterol metabolism and is not considered to be a major initial factor in the growth inhibitory activity of the inhibitors. The increase in free fatty acids does not occur in all cases (42,50). The decrease in oleic acid, which is accompanied by an increase in linoleic and in some cases linolenic acid, is particularly pronounced in, but not restricted to, the polar lipid... 

The relationship between pyridoxine and oleic acid appears to be opposite to that of pyridoxine and the EFA. Thus, Sarma et al. (1947) observed that the growth inhibition in rats caused by feeding diets deficient in pyridoxine or pyridoxal was accentuated when oleic acid was added to the diet. However, the inhibitory action of oleate could be counteracted by the administration of additional quantities of vitamin B . Sinclair (1952) has recently reviewed the relationship between pyridoxine and the EFA. 

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