Oleic acid antitumor activity

To characterize the antitumor and/or antimetastatic activities, the effects of carp oil and oleic acid on DNA synthesis in LLC cells, adherence of LLC cells to human adult dermal microvascular endothelial cells (HMVEC), and Matrigel-induced angiogenesis (in vitro and in vivo) were tested. Carp oil inhibited DNA synthesis in LLC cells at 100 and 1000 pg/mL, but not at 0.1 to 10 pg/mL Table (10) . Oleic acid inhibited DNA synthesis in LLC cells at 1000 pM Table (11) . Carp oil inhibited the Matrigel-induced tube-like network formation of HMVEC at 1000 pg/mL, but not at 0.1 to 100 pg/mL Table (10) . 

On the other hand, the inhibitory actions of oleic acid on metastasis in the liver and metastatic tumor growth in the liver, cannot be explained by the effects of DNA synthesis in LLC cells, and microvascular endothelial cells, or the adherence of LLC cells to the microvascular endothelium rather, these inhibitory actions by oleic acid are partly attributable to the inhibition of the angiogenesis induced by tumors. In conclusion, it seems likely that the antitumor and antimetastatic activities of carp oil may be partly ascribed to a fatty acid, oleic acid, as an active substance. However, the antitumor and antimetastatic effects of carp oil are insufficiently by themselves to explain the action of oleic acid. Further work is in progress to identify the active substance(s) in carp oil. 

An acidic fi action composed of four free acids, palmitic, stearic, oleic and linoleic acids, shows antitumor activity a-monolinolein inhibits tumorigenesis (49) three glycans (coixans A, B, and C) show hypoglycemic activity (50) and a benzoxazinone and a benzoxazolinone exhibit anti-inflammatory activity (51). 

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