Of D-galactosamine

Suda H, Masui T, Ikawa E, et al. 1987. Compared promoting potential of D- galactosamine, carbon tetrachloride and partial hepatectomy in rapid induction of prenaoplastic liver lesions in the rat. Cancer Lett 37 163-171. 

C. Leteux and A. Veyrieres, Synthesis of a-C-glycopyranosides of D-galactosamine and D-glucosamine via iodocyclization of corresponding glycals and silver tetrafluoroboranuide-promoted alkynylation at the anomeric center, J. Chem. Soc., Perkin Trans. 1, (1994) 2647-2655. 

Femandez-Bolanos, J G, Zafra, E, Garcia, S, Eemandez-Bolanos, J, Euentes, J, 4-Thiopyranoside and 4-thiofuranoside derivatives of D-galactosamine, Carbohydr. Res., 305, 33-41, 1998. 

Adaramoye, O. A. Adeyemi, E. O., Hepatoprotection of D-galactosamine-induced toxicity in mice by piuified fractions from Garcinia kola seeds, Basic Clin. Pharm. Toxicol, 2006, 98, 135-141. 

Mihas A A, Ceballos R, Mihas TA, Hirshowitz BI (1990) Modification of the hepatotoxic-ity of D-galactosamine in the rat by an anti-endotoxin. J Med 21 301-311 Miyai K, Slusser RJ, Ruebner BH (1962) Viral hepatitis in mice an electron microscopic study. Exp Mol Pathol 2 464-480... 

Kawano, N., Egashira, Y., and Sanada, H. (2007a). Effect of dietary fiber in edible seaweeds on the development of D-galactosamine-induced hepatopathy in rats. /. Nutr. Sci. 

Orotic acid prevents experimental hepatitis induced by D-galactosamine. The experimental hepatitis paralleled by the accumulation of UDP derivatives of D-galactosamine was studied by Decker and co-workers [382-384]. On the basis of ultrastructural and biochemical analyses it was concluded that the liver damage observed after D-galactosamine treatment differs from that seen in human hepatitis in that the former leads to accumulation of liver triglycerides, hyperplasia of the smooth endoplasmic reticulum, and cell necrosis [385,386]. 

In earlier work we showed that the toxic effect of D-galactosamine on the liver can be inhibited by tryptophan and methionine (5). Furthermore, we found that D-galactosamine influences ADP-ribose metabolism (6). On the other hand it was reported that galactosamine enhances the effect of endotoxin (7). As already mentioned in the introduction, inhibitors of ADP-ribosylation reduce markedly the effect of endotoxin (1). These results stimulated us to study the effect of MDP on the ADP-ribose metabolism and we found indications for the interference of MDP with this metabolism (2). The induction of viral hepatitis by MHV3 in mice can be inhibited to a large extent by MDP and by benzamide. These are indications that the ADP-ribose metabolism plays a key role in the development of the hepatitis. 

Recently, Ehmcan et al. modified N-(2-hydroxypropyl)methacrylamide copolymers by introducing a small amount of D-galactosamine, E>-glucosamine and D-mannosamine residues. Binding was performed by aminolysis of p-nitrophenjd ester groups. Tyrosine residues were also incorporated into... 

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