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Galactosamine D-

The amino sugars include D-glucosamine, a constiment of hyaluronic acid (Figure 13-10), D-galactosamine (chondrosamine), a constituent of chondroitin and D-mannosamine. Several antibiotics (eg, erythromycin) contain amino sugars believed to be important for their antibiotic activity. [Pg.106]

Fig. 9.—Possible Intermediates in the Metabolism and Intereonversion of d-G1u-cosamine and D-Galactosamine. Fig. 9.—Possible Intermediates in the Metabolism and Intereonversion of d-G1u-cosamine and D-Galactosamine.
Amino-2-deoxy-D-galactose (D-galactosamine chondrosamine) H HO HO H HOHjC—C—C—C—C—CHO HO H H NH, frog-spawn mucin blood-group substances cartilage... [Pg.259]

PHA Red kidney bean A-Acetyl-D-galactosamine IV-Acetyl-D-galactosamine... [Pg.151]

ELB Elderberry bark Sialic acid or A-acetyl-D-galactosamine Lactose... [Pg.151]

TLR3 -/- mice had a decreased response to pol(I C) reduced production of TNF, IL-6, IL-12, and resistance to the lethal effect of poly(I C) when sensitized to D-galactosamine [126],... [Pg.316]

Nitroglycals65 are excellent Michael-type acceptors,66 where O-, N-, S-, C- and P-nucleophiles can be used as donors.67 An application of this kind of reaction was reported by Schmidt et al. for a new synthesis of 2-deoxy-2-nitro-D-galactose nucleoside 86 and of /V-acetyl-D-galactosamine nucleoside 88, based on addition reactions to 3,4,6-tri-0-benzyl-2-nitro-D-galactal 85 (Scheme 28).68... [Pg.183]

It is suggested that oxidative degradation of D-mannosamine, D-galactosamine, and D-glucosamine by CAB involves attack of an anomeric alkoxide on CAB as a source of C1+ followed by elimination to lactone. ... [Pg.230]

Acetyls alley lie acid was shown to prevent cirrhosis under certain experimental conditions [125]. Naproxen and indomethacin partially protected against LPS and D-galactosamine-in-duced hepatotoxicity [126] Acetylsalicylic acid and ibuprofen were also protective in endo-toxic shock [127]. Endotoxaemia is one of the complications in cirrhotic patients [128] and is probably caused by an impaired ability of the liver to take up and detoxify gut-derived LPS [116]. The presence of portosystemic shunts in cirrhotic patients may also contribute to this spill-over of LPS into the systemic circulation [129]. NSAIDs, however, are also reported to provoke deleterious effects on renal function in cirrhosis [130], and can therefore not be used in cirrhotic patients. Cell-specific delivery of NSAIDs to SECs and/or KCs may make application of these drugs in cirrhosis feasible by circumventing the renal side-effects. [Pg.104]

The acetylated amino sugars N-acetyl-D-glucosamine and N-acetyl-D-Galactosamine (4) are often encountered as components of glycoproteins. [Pg.38]

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A -Acetyl-D-galactosamine

A-D-Galactosamine-1 -phosphate

Af-Acetyl-D-galactosamine

D-Galactosamine, synthesis

Galactosamine

N Acetyl d galactosamine

Of D-galactosamine

The Methyl Ethers of D-Galactosamine

V-Acetyl-D-galactosamine

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