Hepatitis Experimental

SAFETY PROFILE Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion wakefulness, blood pressure lowering, constipation, hepatitis, fibrous hepatitis. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. Used as a drug for the treatment of depression. When heated to decomposition it emits very toxic fumes of SOx and NO. ... 

Several compounds have been used in treating chronic viral hepatitis. Experimental and clinical studies have focused on four groups of substances (7.) antiviral agents, (2.) immunostimulants, (i.) molecular biological agents, and 4.) adjuvant medicinal remedies. The rate of spontaneous seroconversion is 8-15%lyear... 

Intoxication by aflatoxkis is referred to as aflatoxicosis. Edema and necrosis of hepatic and renal tissues seem characteristic of aflatoxicosis, and hemorrhagic enteritis accompanied by nervous symptoms often appear ki experimental animals. The mode of action of aflatoxkis kivolve an kiteraction with DNA and inhibition of the polymerases responsible for DNA and RNA synthesis (96). 

Albendazole is contraindicated in patients with known hypersensitivity to the drug and during pregnancy (Category C). The drug has exhibited embiyotoxic and teratogenic effects in experimental animals. Albendazole is used cautiously in patients witii hepatic impairment and during lactation. The effects of albendazole are increased with dexamethasone and cimetidina... 

EAE experimental autoimmune encephalomyehtis, MHVmmmt hepatitis virus, LCMVlymphocytic choriomeningitis virus, MS multiple sclerosis, IWWWest Nile virus, TBEVtick-borne encephalitis virus... 

Britton, R.S., Ferrali, M., Magieri, C.J., Recknagel, R.O. and Bacon B.R, (1990b). Increased prooxidant action of hepatic cytosolic low-molecular-weight iron in experimental iron overload. Hepatology 11, 1038-1043. 

KS Pang, M Rowland. Hepatic clearance of drugs. II. Experimental evidence for acceptance of the well-stirred model over the parallel tube model using lido-caine in the perfused rat liver in situ preparation. J Pharmacokin Biopharm 5/6 655— 699, 1977. 

Moroni F, Lombardi G, Moneti G, Cortesini C The release and neosynthesis of glutamic acid are increased in experimental models of hepatic encephalopathy. J Neurochem 1983 40 850-854. 

Baraldi M, Zeneroli ML Experimental hepatic encephalopathy Changes in the binding of gamma-aminobutyric acid. Science 1982 216 427-429. 

Basile AS, Gammal SH, Jones EA, Skolnick P GABA-A receptor complex in an experimental model of hepatic encephalopathy Evidence for elevated levels of an endogenous benzodiazepine receptor complex ligand. J Neurochem 1989 53 1057-1063. 

Arivazhagan S, Velmurugan B, Bhuvaneswari V and Nagini S. 2004. Effects of aqueous extracts of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidant-antioxidant status during experimental gastric carcinogenesis. J Med Food 7(3) 334—339. 

---