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Ribose metabolism

Diefenbach J, Burkle A (2005) Introduction to poly(ADP-ribose) metabolism. Cell Mol Life Sci 62 721-730... [Pg.65]

Lee, H.C., Galione, A. und Walseth, T.F. Cyclic ADP-ribose metabolism and calcium mobilizing function (1994) Vitam. Horm. 48,199-257... [Pg.245]

Chini EN, de Toledo EG, Thompson MA, and Dousa TP (1997) Effect of estrogen upon cyclic ADP ribose metabolism beta-estradiol stimulates ADP ribosyl cyclase in rat uterus. Proceedings of the National Academy of ScierKes of the USA 94, 5872-6. [Pg.419]

Lautier D, Lagueux J, Thibodeau J, Menard L, Poirier GG. Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol Cell Biochem 1993 122 171-93. [Pg.1153]

H6. Hiatt, H. H., Studies of ribose metabolism. II. A method for the study of ribose synthesis in vivo. J. Biol. Chem. 229, 725-730 (1957). [Pg.203]

Davidovic L, Vodenicharov M, Affar EB et al. Importance of poly(ADPribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Exp Cell Res 2001 268(1) 7-13. [Pg.12]

In eukaryotic cells, DNA damage may induce a several thousand fold stimulation of poly(ADP-ribose) metabolism. A few restrictions and rules apply yeast does not express such a response, and in all other eukaryotes tested so far, the most effective types of DNA damages are those that are substrates for the DNA base excision repair pathway. By far the largest amount of ADP-ribose is processed throi the catalytic domains of two nuclear enzymes poly(ADP-ribose)polymerase-l, (PARP-1), and its catabolic counterpart, poly(ADP-ribose)glycohydrolase (PARC). Other members of the growing PARP family may contribute to this metabolism, albeit to a much lesser extent and with mechanisms that await further elucidation (for reviews see refs. 1,2). [Pg.41]

The poly(ADP-ribose) metabolism arising from the cooperation of PARP-1 and PARC is involved in DNA base excision repair and in DNA dama s naling to cell survival/cell death pathways. The present review focuses on a particular aspect of poly(ADP-ribose) signaling when PARP-1 is activated, it catalyzes poIy(ADP-ribose) synthesis on itself ( automodification). The polymers on PARP-1 can then recruit other proteins into multiprotein complexes and reprogram their domain functions. [Pg.41]

Whitacre CM, Hashimoto H, Tsai ML et al. Involvement of polyfADP-ribose) metabolism in p53 regulation and its consequences. Cancer Res 1995 55 3697-3701. [Pg.50]

Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and m the Maintenance of Neuronal Integrity... [Pg.51]

Understanding poIy(ADP-ribose) metabolism has an important impaa for unraveling fundamental biological mechanisms ranging from chromosomal instability in cancer, the morphogenesis of the tissues and the maintenance of neuronal cell functions. [Pg.51]

Since both the modification of poly(ADP-ribose) by PARP-1 and the d radadon of poly(ADP-ribose) after DNA damage occur quite rapidly, it follows that poly(ADP-ribose) metabolism in the cells is highly dynamic process. [Pg.52]

Jonsson GG, Jacobson EL, Jacobson MK. Mechanism of alteration of poly(adenosine diphosphate-ribose) metabolism by hyperthermia. Cancer Res 1988 48(15) 4233-9. [Pg.114]

Poly(ADP-ribose) metabolism is a chromatin associated event. The function of poly-(ADP-ribose) may be mediated by activation or inactivation of enzymatic activities by the covalent binding of the polymer and/or by noncovalent interactions of this highly negatively charged polymer with other chromatin components. We have studied the size distribution and branching frequency of polymers in order to evaluate the potential importance on noncovalent interactions with other components of chromatin. [Pg.32]

Juarez-Salinas H, Duran-Torres G, Jacobson MK (1984) Alteration of poly(ADP-ribose) metabolism by hyperthermia. Biochem Biophys Res Commun 122 1381-1388... [Pg.127]

Jacobson EL, Antol KM, Juarez-Salinas H, Jacobson MK (1983) Poly(ADP-ribose) metabolism in ultraviolet irradiated human fibroblasts. J Biol Chem 258 103-107... [Pg.196]

To provide further independent evidence of ADPRT involvement in DNA repair and to investigate the molecular mechanisms of this involvement we have isolated cell variants altered in (ADP-ribose)n metabolism from mammalian cells. After mutagenesis variants were selected for resistance to the combined effect of SAB and dimethyl sulphate (DMS). It was presumed that some variants would arise as a result of alterations in (ADP-ribose) metabolism and/or in enzymes involved in DNA repair. [Pg.289]

Poly(ADP-Ribose) Metabolism in Vivo Following DNA Damage... [Pg.293]

See other pages where Ribose metabolism is mentioned: [Pg.89]    [Pg.104]    [Pg.684]    [Pg.297]    [Pg.1]    [Pg.1]    [Pg.3]    [Pg.5]    [Pg.9]    [Pg.41]    [Pg.44]    [Pg.55]    [Pg.106]    [Pg.150]    [Pg.277]    [Pg.282]    [Pg.293]    [Pg.294]   
See also in sourсe #XX -- [ Pg.230 ]

See also in sourсe #XX -- [ Pg.213 , Pg.214 , Pg.215 , Pg.216 ]



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