Odorant receptors repertoire

Alioto TS, Ngai J (2005) The odorant receptor repertoire of teleost fish. BMC Genomics 6 173... 

Alioto TS, Ngai J (2005) The odorant receptor repertoire of teleost fish. BMC Genomics 6 173 Anton S et al (2003) Central projections of olfactory receptor neurons from single antennal and palpal sensilla in mosquitoes. Arthropod Struct Dev 32 319-327 Bartelt RJ et al (1985) cis-Vaccenyl acetate as an aggregation pheromone in Drosophila mela-nogaster. J Chem Ecol 11 1747-1756... 

Mombaerts, P. (2001) The human repertoire of odorant receptor genes and pseudogenes. Annu. Rev. Genomics Hum. Genet. 2, 493-510. 

Hashiguchi Y, Nishida M (2006) Evolution and origin of vomeronasal-type odorant receptor gene repertoire in fishes. BMC Evol Biol 6 76... 

Hansen A, Rolen SH, Anderson K, Morita Y, Caprio J, Finger TE (2003) Correlation between olfactory receptor cell type and function in the channel catfish. J Neurosci 23 9328-9339 Hansen A, Anderson KT, Finger TE (2004) Differential distribution of olfactory receptor neurons in goldfish structural and molecular correlates. J Comp Neurol 477 347-359 Hashiguchi Y, Nishida M (2006) Evolution and origin of vomeronasal-type odorant receptor gene repertoire in fishes. BMC Evol Biol 6 76... 

Hallem EA, Carlson JR (2006) Coding of odors by a receptor repertoire. Cell 125 143-160 Heimbeck G et al (1999) Smell and taste perception in Drosophila melanogaster larva toxin expression studies in chemosensory neurons. J Neurosci 19 6599-6609 Heisenberg M (2003) Mushroom body memoir from maps to models. Nat Rev Neurosci 4 266-275... 

Odour perception has been compared with the immune system. But receptor activation in the olfactory system seems to have an instructive rather than a selective role. An instructive role would be in agreement with the large genetic repertoire coding for a receptor for each type of odorant molecule. 

Fuss SH, Korsching SI (2001) Odorant feature detection activity mapping of structure response relationships in the zebrafish olfactory bulb. J Neurosci 21 8396-8407 Gloriam DE, Bjarnadottir TK, Yan YL, Postlethwait JH, Schioth HB, Fredriksson R (2005) The repertoire of trace amine G-protein-coupled receptors large expansion in zebrafish. Mol Phylogenet Evol 35 470-482... 

In most mammalian species, two functionally distinct classes of chemicals (odorants and pheromones) are detected and processed through anatomically segregated neural pathways the main olfactory system and the vomeronasal (accessory olfactory) system (Buck 2000 Mombaerts 2004). Volatile odorants are received by a large repertoire of ORs expressed on ciliated OSNs in the OE and the information is transmitted to the main OB. By contrast, pheromones are mostly received by two families of vomeronasal receptors (VIRs and V2Rs) expressed on microvillous sensory neurons in the vomeronasal organ that project their axons to the accessory OB. 

The diversity of human olfactory acuity, as defined by specific anosmia, may be caused by the diversity of the olfactory receptor protein repertoire in humans. Physiologically, humans have a limited number of clearly defined olfactory receptor types that modulate odor perception in response to a small recurrent set of odorants distributed throughout the natural world. For example, the Flavornet lists about 500 chemicals reported to be above their threshold in natural products [39,40]. Natural products contain a subset of functional odorants, above their threshold, that invoke perceptions that humans experience as odor. The same odorants are found in many natural products but in different relative concentrations. Tested individually, these odorants produce precepts that have been... 

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