Octyl salicylate sunscreen

These sunscreen ingredients include octyl-dimethyl-PABA (UVB), 2-ethylhexyl-p-meth-oxycinnamate (UVB),octocrylene (UVA/UVB), octyl salicylate (UVB), benzophenones (UVB/ UVA), and methyl anthranilate (UVA). Avoben-zone or Parsol 1789 and mexoryl, a benzylidene camphor, block UVA. Mexoryl is the most efficient of the UVA organic sunscreens [10]. Many sunscreen formulations combine ingredients to maximize photoprotection. 

Walters, K.A. Brain, K.R. Howes, D. James, V.J. Kraus, A.L. Teetsel, N.M. Toulon, M. Watkinson, A.C. Gettings, S.D. Percutaneous penetration of octyl salicylate from representative sunscreen formulations through human skin in vitro. Fd. Chem. Toxicol. 1997, 35, 1219-1225. 

Octyl methoxycinnamate Salicylates / Anthranilates Methyl salicylate Menthyl salicylate Menthyl anthranilate Octyl salicylate Physical Sunscreens... 

Beilstein Handbook Reference) Benzoic acid, 2-hydroxy-, 2-ethylhexyl eslen BRN 2730664 Dermoblock OS EINECS 204-263-4 Ethyl hexyl salicylate 2-Ethylhexyl salicylate Ethylhexyl salicylate 2-Ethylhexyl 2-hydroxybenzoate Neo Heliopan OS NSC 46151 Octisalate Octyl salicylate Salicylic acid, 2-ethylhexyl ester Sunarome 0 Sunarome WMO USAF DO-11 Uvinul 0-18 WMO. UV-B absorber for cosmetic applicabons, waterproof sunscreens solubilizer for oxybenzone. Solid bp2i = 189-190° d = 1.014. Akzo Chemie BASF Corp. Haarmann Reimer GmbH. 

The in vitro human skin permeation of a commonly used sunscreen active, octyl salicylate (2-ethylhexyl salicylate) was determined from two vehicles (an oil-in-water emulsion and a hydroalcoholic formulation) that were representative of typical commercial sunscreen products (Walters, Brain, Howes, etal., 1997). Human abdominal skin that was obtained at autopsy was heat separated to yield epidermal membranes (comprising stratum comeum and viable epidermis) and mounted in glass horizontal-type diffusion cells. Receptor phase solutions consisted of phosphate-buffered saline, pH 7.4, containing 6% Volpo N20 to ensure sink conditions. A finite dose of the oil-in-water emulsion formulation (5 mg/cm ) and hydroalcoholic... 

Table 8.3 Permeation and Recovery Data for Octyl Salicylate After Application as Finite Doses In Vitro in Typical Sunscreen Vehicles...

Uses Plasticizer, emollient, skin conditioner, solvent, carrier, pigment wetting agent/dispersant, lubricant in cosmetics, creams/lotions, hair care, skin care solvent for sunscreen actives Manuf/Distrib. HallStar Butyl octyl salicylate... 

Another very common use of phenolic compounds is in sunscreens. The presence of the aromatic ring results in the effective absorbance of the UV-B radiation (between 280 and 315 nm) from the sun and thus prevents sunburns. The most common active ingredient in many sunscreens is p-aminobenzoic acid (PABA 7.1), which is actually not a phenolic compound. This compound has been widely used since the 1970 s but is less popular nowadays due to the formation of skin rashes and acne. As a result many sunscreens are now PABA-free. Alternative active ingredients include salicylates such as octylsalicylate (7.2), cinnamates such as octyl methylcinnamate (7.3), benzophenone (7.4) and the related compound oxybenzone (7.5), and anthranilates, such as menthylanthranilate (7.6). Octyl methylcinnamate (7.3) is insoluble in water and is therefore commonly... 

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