Octyl-4-methoxycinnamate

Octyl methoxycinnamate (OMC) is the most common UV-B sunscreen that is on the market Eisenstadt, A. In Catalysis of Organic Reactions Herkes, F. E., Ed. Marcel Dekker New York, 1998 Chapter 33. 

Ocfylhexaoxyethylene glycol, monoether micellization of, 24 131t Octyl methoxycinnamate cosmetic uv absorber, 7 846t function as ingredient in cosmetics, 7 829t... 

Asai, M., Kawada, A., Aragane, Y., Yudate, T., Isogai, R., and Tezuka, T., Contact dermatitis due to octyl methoxycinnamate and butyl methoxydibenzoylmethane with photoaggravation, Environ. Dermatol. Jpn), 8, 28, 2001. 

Janjua NR, Mogensen B, Andersson AM. Systemic absorption of the sunscreens benzo-phenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. J Invest Dermatol 2004 123 57-61. 

The industrial synthesis of octyl methoxycinnamate, a common ingredient in sunscreens. 

Spectrally related to anticipated protection. In practice, the spectral profiles before and after exposure are compared and any changes are interpreted as photoinstability. This is a very crude analysis, not allowing one to identify reversible transformations, which after an equilibration phase may lead to stable systems (e.g., ethylhexyl methoxycinnamate [EHMC, formerly OMC (octyl methoxycinnamate)]. Because it gives an overall profile, it is also not possible, in the case of complex mixtures, to know which filter is doing what. 

Very little is known about the distribution and metabolism of sunscreens in humans, but animal studies showed that benzophenone-3 undergoes substantial dermal metabolism and protein binding in rats (257, 258), and is excreted in both urine and feces. Excretion of several sunscreening agents (including benzophenone-3 and octyl methoxycinnamate) in human breast milk after normal use has been reported (259). 

Octyl methoxycinnamate Salicylates / Anthranilates Methyl salicylate Menthyl salicylate Menthyl anthranilate Octyl salicylate Physical Sunscreens... 

Many consumers desire the additional lip treatment feature of protection from damaging type A and/or B solar UV radiation. Added active sunscreen ingredients must be safe when ingested in small amounts and not interfere with product esthetic characteristics. These chemicals usually include UV-B protectors such as octyl methoxycinnamate and padimate O and UV-A protectors such as oxybenzone added at concentrations ranging from 7.5 to 1.5 percent. 

Nonsubstantive photofilters, such as salicylic acid derivatives and octyl methoxycinnamate or benzophenone derivatives, have been included in leave-on formulations for skin and hair. Revlon possesses a patent describing the use of benzophenone and PABA derivatives with cationic surfactants and nonionic film formers in a mousse for hair protection [84], L Oreal has included camphorbenzalkonium sulfate as a proprietary photofilter in hair and skin care formulations [85-92],... 

OMC (Octyl -methoxycinnamate) is the most common UV-B sunscreen on the market with an estimated world consumption of ca 5000 tons year The production of this compound is an example of the novel chemistry and economic attractiveness of the Heck reaction on an industrial scale. 

The active ingredients in octyl methoxycinnamate, octyl salicylate, and oxybenzone gel are octyl methoxycinnamate 7.5%, octyl salicylate 4%, and oxybenzone 3%. The inactive ingredients are purified water, Cl2-15 alkyl benzoate, cetearyl alcohol and ceteareth-20, cetyl alcohol,... 

Unifilter U-41. [Induchem AG] Butyl methoxydibenzoylmethane, octyl methoxycinnamate, 3-benzylidene canqAor. 

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