Nutrient interaction effects

The nutrient sparing effect of antibiotics may result from reduction or elimination of bacteria competing for consumed and available nutrients. It is also recognized that certain bacteria synthesize vitamins (qv), amino acids (qv), or proteins that may be utilized by the host animal. Support of this mode of action is found in the observed nutritional interactions with subtherapeutic use of antibiotics in animal feeds. Protein concentration and digestibiHty, and amino acid composition of consumed proteins may all influence the magnitude of response to feeding antibiotics. Positive effects appear to be largest... 

Microencapsulation and Related Drug Processes, Patrick B. Deasy Drugs and Nutrients The Interactive Effects, edited by Daphne A. Roe and T. Colin Campbell... 

Reports of lead-nutrient interactions in experimental animals have generally described such relationships in terms of a single nutrient, using relative absorption or tissue retention in the animal to index the effect. Most of the data are concerned with the impact of dietary levels of calcium, iron, phosphorus, and vitamin D. These interaction studies are summarized in Table 2-12. 

The most significant drug-nutrient interactions result in reduced bioavailability and suboptimal pharmacologic effect (Table 58-4). Continuous feeding requires interruption for drug administration and medications... 

The role of allelochemic-nutrient interactions in insect dietetics has been investigated only rarely. Examples of such interactions abound in vertebrate literature (14, 15) and may supply useful leads for researchers working with Insects. Many of the deleterious physiological effects of plant allelochemics may be due primarily to various interactions between these allelochemics and essential nutrients. In other words, it is Important to not only consider the presence of nutrients, but also the "bio-availability" of these nutrients to the phytophagous Insect. 

Although the human genome project and subsequent efforts have sparked interest in the effects of SNPs on common diseases, the intersection of genomics and nutrition is relatively unexplored. To this end, nutritional genomics has emerged as a discipline that seeks to provide information on gene-nutrient interactions (and vice... 

Another kind of environmental interaction may result when in a homeostatic adjustment to the pollutant, the plant sacrifices part of its capacity to respond to environmental fluctuations. For example, the metabolic adjustment to fluorides may increase the susceptibility to nutrient stress. This hypothesis could explain why some symptoms of chronic fluoride toxicity resemble those produced by Mn, Fe, or Zn deficiencies. If air pollution is one environmental factor that alters the susceptibility of the plant to other environmental stress, it would also be logical to expect an interaction between pollutants if the receptor is exposed to two or more of them. Such interactive effects have been found. Sub-threshold concentrations of SOL> and 03 or S02 and N02 produce foliar lesions when plants are exposed to both pollutants (34). Additionally, plants exposed to S02 differ from non-fumigated plants in their resistance to subsequent fumigations (35). Thus the plants susceptibility or capacity to adapt to a pollutant is altered by concurrent exposures to another or consecutive exposures to the same one. 

Burton KW, Morgan E, Roig A. 1986. Interactive effects of cadmium, copper and nickel on the growth of Sitka Spruce and studies of metal uptake from nutrient solutions. New Phytol 103 549-557. 

Johansson, O., Lindberg, T., Melander, A. and Wahlin-Boll, E. (1985) Different effects of different nutrients on theophylline absorption in man. Drug-Nutrient Interactions, 3 (4), 205-211. 

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