Protein nuclear

To solubilized lat hepatic nuclear protein receptor Affinities and potencies are relative to L-T taken as 1 (6). 

The antagonist-induced conformation of nuclear hormone receptors attracts co-repressors like Nco/SMRT (nuclear hormone receptor co-repressor/silencing mediator of retinoid and thyroid receptors) which further recruit other nuclear proteins with histone deacetylase activity. Their action leads to chromatin condensation, thus preventing the general transcription apparatus from binding to promoter regions. 

The assembly of nucleosomes is mediated by one of several chromatin assembly factors facilitated by histone chaperones, proteins such as the anionic nuclear protein nucleoplasmin. As the nucleosome is assembled, histones are released from the histone chaperones. Nucleosomes appear to exhibit preference for certain regions on specific DNA molecules, but the basis for this nonrandom distribution, termed phasing, is not completely... 

Biotin also has a role in regulation of the cell cycle, acting to biotinylate key nuclear proteins. 

Paquet F, Durand J-P, Goudard F, et al. 1993. Distribution of [241Am] in hepato-pancreatic nuclear proteins of the lobster (Homarus gammarus). Biochem Mol Biol Int 29(4) 635-644. 

R18. Russell, D. H New aspects of prolactin and immunity A lymphocyte-derived prolactin-like product and nuclear protein kinase C activation. Trends Pharmacol. Sci. 10,40-44 (1989). 

Vaessin H, Grell E, Wolff E, Bier E, Jan LY, Jan YN 1991 prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell 67 941-953... 

Baldin, V., Lukas, J., Marcote, M.J., Pagano, M., and Draetta, G. 1993. Cyclin D1 is a nuclear protein required for cell cycle progression in Gl. Genes Dev 7 812-821. 

The primary Junction of the nucleosomes is to condense DNA. Further condensation of nucleosome DNA requires nonhistone nuclear proteins. These proteins make up a scaffoldlike structure around an additional helix consisting of coiled nucleosomes. This produces a structure that resembles a solenoid, with six nucleosome subunits per turn. The solenoid structure can form large loops that give additional structure to the incipient chromosome. 

Other oncogenes code for proteins that bind guanine nucleotides, and others code for nuclear proteins. The guanine nucleotide-binding proteins, the so-called G proteins, affect several key reactions. Some G proteins are stimulatory, whereas others are inhibitory. For example, they link hormone receptors to adenylate cyclase, they translocate... 

Adam, SA., Marr, R. S., and Gerace, L. (1990). Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. Ill, 807—816. 

Tf-containing PEG-shielded polyplexes have also been applied for systemic tumor-targeted delivery of siRNA [106-108]. Systemic treatment of Neuro 2A tumorbearing mice using Tf-PEG-shielded crosslinked oligoethylenimines for delivery of siRNA against Ras-related nuclear protein (Ran) led to >80% reduced Ran protein expression, associated with tumor apoptosis and reduced tumor growth [108]. 

Histones and nonhistone nuclear proteins Ribosomal protein S6 elF (eukaryotic initiation factor) eEF (eukaryotic elongation factor)... 

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