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Nuclear, plastid transformations

Since thousands of copies of the plastid genome can be found per plant cell, extremely high levels of foreign protein are able to accumulate in plants that harbor transgenic chloroplasts. Expression levels greater than 40% of total soluble cellular protein, or 10-100 times higher than protein expression from nuclear transformants, have been detected from plastid transformants. [Pg.65]

In conclusion, plastid-based expression systems provide for potentially higher expression levels than the majority of nuclear expression systems, and with a higher level of transgene containment, but the platform provides limited post-translational processing choices. Also, despite reports of successful plastid transformation of new species beyond Nicotiana, the choice of production host is stiU predominantly restricted to the Nicotiana family. However, this hmita-tion does not present a serious drawback for production of pharmaceutical proteins (except perhaps for edible vaccines ) since tobacco is a non-feed/non-food crop with a weU-estabhshed agriculture. [Pg.900]

Apt KE, Kroth-Pancic PG and Grossman AR (1996) Stable transformation nuclear transformation of the diatom Phaeodactylum tricomutum. Mol Gen Genet 252 572-579 Bhaya D and Grossman AR (1991) Targeting proteins to diatom plastids involves transport through an endoplasmic reticulum. Mol Gen Genet 229 400-404... [Pg.96]


See other pages where Nuclear, plastid transformations is mentioned: [Pg.207]    [Pg.16]    [Pg.59]    [Pg.60]    [Pg.66]    [Pg.69]    [Pg.2196]    [Pg.899]    [Pg.195]    [Pg.103]    [Pg.115]    [Pg.59]    [Pg.64]    [Pg.226]    [Pg.899]    [Pg.610]    [Pg.612]    [Pg.196]    [Pg.2750]    [Pg.383]   


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Nuclear, plastid transformations contrasted

Plastid

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