Novel targets

Components of the JAK-STAT signaling pathway represent novel targets for pharmacological interventions [4]. Recently, a specific and orally active JAK3 antagonist was identified from screening of a chemical library for inhibitors of in vitro JAK3 kinase activity. The most effective compound, CP-690,550, was shown... 

Catlett-Falcone R, Dalton WS, Jove R (1999) STAT proteins as novel targets for cancer therapy. Curr Opin Oncol 11 490-496... 

Mijatovic T, Roland I, Van Quaquebeke E et al (2007) The alphal subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers. J Pathol 212 170-9... 

The PAR family represents a novel target for drug therapy. Therapeutic approaches with most clinical benefit may rely upon the development of both agonists and antagonists, either of which could be utilised dqiending upon the disease condition [3]. 

Stein U, Arlt F, Walther W et al (2006) The metastasis-associated gene S100A4 is a novel target of p-catenin/ T-cell factor signaling in colon cancer. Gastroenterology 131 1486-1500... 

Wondrak, G. T. Jacobson, M. K. Jacobson, E. L. (2006). Endogenous UVA photosensitizers mediators of skin photodamage and novel targets for skin photoprotection. Photochemical Photohiological Sciences, Vol.5, (nd), (August 2005), pp. 215 - 237, ISSN 1474-905X. 

Ludwig S (2007) Influenza viruses and MAP kinase cascades - novel targets for antiviral intervention, Signal Transduction 7 81-88... 

Grosser N et al (2004) The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells. Free Radic Biol Med 37(12) 2064-2071... 

Perry, AS, B Loftus, R Moroose et al. 2007. In silico mining identifies IGFBP-3 as a novel target of methylation in prostate cancer. BrJ Cancer 96 1587-1594. 

Castro, L. M., Gallant, M. Niles, L. P. (2005). Novel targets for valproic acid ... 

Name three potential novel targets and drugs for treating schizophrenia in the future. 

Wang JF, Young LT. Differential display PCR reveals novel targets for the mood-stabilizing dmg valproate including the molecular chaperone GRP78. Mol Pharmacol 1999 55 521-527. 

The emphasis of the program is to support projects that complement, rather than compete with the private sector. Some examples are projects related to high-risk and novel targets, orphan diseases, and areas in which the monetary return may not be immediately clear. 

Having said all this, a recent report from a major pharmaceutical company with one of the largest reported screening collections revealed that just over 50% of their current lead optimization efforts invoke a "fast follower" approach [114]. Why is this One might speculate that as most companies work on the same targets these days chemists find it easier to "patent bust" than wait for the results of an HTS campaign which may take months to develop. Possibly, when more novel targets are identified, HTS of enhanced collections will deliver upon the promise that they hold. 

Mattson, M. P. and Kroemer, G. Mitochondria in cell death novel targets for neuro- and cardio-protection. Trends Mol. Med. 9 196-205,2003. 

Lewis, D. A., Volk, D. W. and Hashimoto, T. Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia a novel target for the treatment of working memory dysfunction. Psychopharmacology 174 143-150,... 

Constantini, P., Jacotot, E., Decaudin, D., and Kroemer, G., 2000, Mitochrondrion as a novel target of anticancer chemotherapy, /. of the National Cancer Institute 92 1042-1053. 

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