Phenol, 2-methyl-3-nitro

However, heterocycles containing thiophenols have not been reported. It has been observed that the thiophe-nolate ion undergoes nucleophilic attack by the halo/ nitro compounds more easily than the phenolate ion in displacement reactions [37-39]. The experimental result shows that the reactivity of 3-nitro-N-phenyl-phthali-mide with 4-methyl-thiophenolate (reaction 1) is 100 times faster than that of 4-methyl phenolate [40] (reaction 2) ... 

A subsequent study, using clearly homogeneous conditions, of the dedeutera-tion of [2-2H]-4-nitro-, -chloro-, and -methyl-phenols by aqueous sulphuric acid showed that the rate coefficients clearly increased with increasing acidity (Table 120) and plots of log rate coefficient versus the acidity function — H0 were linear,... 

Die Bamberger-Umlagerung zu Amino-phenolen ist oft Ziel der elektrochemischen Reduktion, so z. B. bei der kathodischen Reduktion von 6-Chlor-2-nitro-toluol zu 2-Chlor-4-amino-3-methyl-phenol (an Pt bis 78% d.Th.)2 und von 2-Chlor-l-nitro-benzol zu 3-Chlor-4-amino-phenol (bis 63% d.Th.)3 (die leicht zu 1,4-Benzochinonen oxidiert werden konnen). 

OH ch3 c6h 5 1 2,6-Dinitro-4-methyl-phenol + 3-Methyl-3-nitro-6-oxo-1,4-cyclohexadien 73 21 - 3... 

Methyl-3-nitrophenol o-Cresol, 3-nitro- (8) Phenol, 2-methyl-3-nitro-(9) (5460-31-1)... 

Annapurna et al. [13] established simple, accurate, and reproducible UV spectrophotometric methods for fhe assay of buclizine based on the formation of precipitation, charge transfer, and redox products. Precipitation/ charge transfer complex formation of fhe buclizine with I2/p-nitro methyl amino phenol sulfate-sulfanilic acid by method A, the precipitation/complex formation with ammonium molybdate/potassium thiocyanate by method B and precipitation/redox reaction of buclizine with phosphomolybdic acid/Co /EDTA by method C were proposed. Determination of buclizine in bulk form and in pharmaceutical formulations was also incorporated. 

Dinitro-o-cresol or 4,5-di-nitro-2-methyl phenol is an yellow crystalline compound having m.p. of 87°C (pure grade). It is pseudoacid and readily forms water-soluble ammonium potassium or sodium salts. 

Nonsubstituted phenols Methyl-phenols Ch loro-phenols Nitro-phenols... 

We have seen that electron-withdrawing substituents increase the acidity of a compound (Sections 1.18 and 7.10). Therefore, when a substituent either withdraws electrons from or donates electrons into a benzene ring, the values of substituted phenols, benzoic acids, and protonated anilines will reflect this withdrawal or donation. For example, the of phenol in H2O at 25 °C is 9.95. The pK of para-m xo-phenol is lower (7.14) because the nitro substituent withdraws electrons from the ring, whereas the pK of para-methyl phenol is higher (10.19) because the methyl substituent donates electrons into the ring. 

Chromatograms obtained from online SPE-HPLC system. The mobile phase for chromatographic separation consisted of 38% CH3 CN, 61% water, and 1% (v/v) acetic acid, with the apparent pH adjusted to 6.0. The flow rate is 1 mL/min. (a) The sample solution consisted of 10 mL double-distilled water spiked with phenols at 10 j.g/L, without washing with acetonitrile (b) the sample solution consisted of 100 mL double-distilled water spiked with phenols at 1 J.g/L, without washing with acetonitrile (c) the sample solution consisted of 100 mL double-distilled water spiked with phenols at 1. g/L, washing with 0.6 mL acetonitrile (d) the sample solution consisted of 100 mL double-distilled water spiked with phenols at 1 j.g/L, washing with 0.6 mL methanol. (1) phenol, (2) 4-nitrophenol, (3) 3-nitrophenol, (4) 2-nitro-phenol, (5) 2,4-dimethylphenol, (6) 4-chloro-3-methyl-phenol, (7) 2,4-dichlorophenol. (Reprinted from Fan, Y., Qi Feng, Y., and Lu Da, S., Anal. Chim. Acta, 484, 145, 2003. With permission.)... 

Phenol, 5-chloro-2-methyl-Phenol, 4-chloro-2-nitro-... 

The earliest reported demonstration of enzymatic activity in a supercritical fluid was for the reaction of disodium p-nitrophenyl phosphate to p-nitro-phenol, catalysed by alkaline phosphatase. Randolph et aL [26] detected the product in yields of up to 71% in carbon dioxide at 35°C and 100 atm, in the presence of 0.1% v/v water. Hammond et al. [33] found tyrosinase, a polyphenol oxidase, to be catalytically active for the oxidation of 4-methyl phenol in both supercritical carbon dioxide at (36 2)°C and supercritical trifluoro-methane at (34 2)°C, with oxygen, at a total pressure of 345 bar. Use of a flow reactor permitted isolation of greater quantities of the catecholic product (1,2-dihydroxy, 4-methylbenzene). Oxidative activity for 4-chlorophenol substrate was appreciably lower. 

Phenol, 4-cyano-Phenol, 3-nitro-Phenol, 2-methyl-Phenol, 3-chloro-Phenol, 4-bromo-Phenol, 2-methyl-4,6-dinitro-Phenol, 2,6-dibromo-4-cyano-(3,5-Dibromo-4-hydroxybenzonitrile) Phenol, 4-tert-butyl-Phenol, 2,4,6-tribromo-Phenol, 2-sec-butyl-4,6-dinitro-Phenol, 2-tert-butyl-4,6-dinitro-Phenol, pentachloro-... 

Polymers. AH nitro alcohols are sources of formaldehyde for cross-linking in polymers of urea, melamine, phenols, resorcinol, etc (see Amino RESINS AND PLASTICS). Nitrodiols and 2-hydroxymethyl-2-nitro-l,3-propanediol can be used as polyols to form polyester or polyurethane products (see Polyesters Urethane polymers). 2-Methyl-2-nitro-l-propanol is used in tires to promote the adhesion of mbber to tire cord (qv). Nitro alcohols are used as hardening agents in photographic processes, and 2-hydroxymethyl-2-nitro-l,3-propanediol is a cross-linking agent for starch adhesives, polyamides, urea resins, or wool, and in tanning operations (17—25). Wrinkle-resistant fabric with reduced free formaldehyde content is obtained by treatment with... 

In mordant dyes, phenols, naphthols, and enolizable carbonyl compounds, such as pyrazolones, are generally the couplers. As a rule, 2 1 metal complexes are formed ia the afterchroming process. A typical example of a mordant dye is Eriochrome Black T (18b) which is made from the important dyestuff iatermediate nitro-l,2,4-acid, 4-amiQO-3-hydroxy-7-nitro-l-naphthalenesulfonic acid [6259-63-8]. Eriochrome Red B [3618-63-1] (49) (Cl Mordant Red 7 Cl 18760) (1, 2,4-acid — l-phenyl-3-methyl-5-pyrazolone) is another example. The equiUbrium of the two tautomeric forms depends on the nature of the solvent. 

Synthetic routes that access appropriately substituted thienobenzazepines are also quite important for medicinal chemistry stracture activity relationship studies, and many involve similar bond connectivity strategies. One notable example employs the use of conunercially available 4-methyl-3-nitrophenol (Scheme 6.3). Methylation of the phenol followed by bromination, hydrolysis, and oxidation of the benzylic alcohol afforded aldehyde 9 in quantitative yield. Treatment of this aldehyde with 5-lithio-2-methylthiophene provided, after dehydroxylation, nitro intermediate A in good overall yield. Reduction of the nitro functionality and treatment with phosgene presented the corresponding isocyanide which upon cychzation using aluminum trichloride in a Friedel-Crafts fashion afforded the... 

The effect of 4-NC>2 on the acidity of phenol is somewhat enhanced by the introduction of methyl groups in the 2,6 positions134. Thus, ApKa values for 4-nitro- and... 

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