2-Amino-4-methyl-6-nitro

The molecule of 4-amino-2-methyl-5-nitro-l,2,3-triazole 1-oxide is nearly planar, except that the hydrogen atoms of the methyl group deviate from the ring plane by 0.505, 0.918, and 0.324 A [175], Coplanarity of the nitro group with the ring plane (1.8°) is caused by intramolecular hydrogen bond O...H...N (the O...N distance is 2.851 A). This fact also explains an elongation of N6-O8 bond (1.233 A) relative to N6-07 (1.225 A). 

Thiazole, 5-amino-4-ethoxycarbonyl-2-methyl-synthesis, 6, 306 Thiazole, 2-amino-4-(2 -furyl)-bromination, 6, 256 Thiazole, 2-amino-4-hydroxy-synthesis, 6, 296 Thiazole, 5-amino-2-hydroxy-synthesis, 6, 301 Thiazole, 5-amino-2-mercapto-synthesis, 6, 301 Thiazole, 2-amino-4-methyl-alkylation, 6, 256 synthesis, 6, 300 Thiazole, 2-amino-5-nitro-antiparasitic activity, 1, 180... 

Atkinson and Taylor summarized the evidence in support of the earlier assumption, arising from the evidence discussed above, that quatemization occurs on N-1 and also showed that 4-amino-, 4-amino-6-nitro-, and 4-amino-7-chloro-cinnoline gave two salts with methyl iodide, while 4-amino-8-nitrocinnoline gave only one salt and the... 

Amino-3-methyl-2(l//)-quinoxalinone 3-Amino-l-methyl-2(l//)-quinoxalinone 4-oxide 3-Amino-7-nitro-2-quinoxalinecarbonitrile... 

The authors of primary Reference 80 present their own and selected literature values for the R—NO bond enthalpies for the hydrocarbyl cases of Me, Et, t-Bu, allyl and benzyl, as well as mixed fluorinated, chlorinated methyl radicals. We now wish to compare nitroso species with the corresponding amino and nitro compounds. Choosing what we consider the most reliable and relevant nitroso compound data, and accompanying them with the corresponding radical data, we derive enthalpies of formation of gaseous nitrosomethane, 2-methyl-2-nitrosopropane and o -nitrosotoluene81 to be 65 2, —29 4 and 174 7 kJmol-1. (By comparison, the earlier values recommended8 for nitrosomethane and 2-methyl-2-nitrosopropane were 70 and —42 kJmol-1 respectively.)... 

Further applications for the determination of the newer antidepressants have employed precolumn derivatization, which included a reaction with dansyl chloride or 4-(N-chloroformylmethyl-N-methyl) amino-7-nitro-2,l,3,-benzoxadiazole (NBD-COCL) followed by separation on ODS Cl8 analytical columns maintained at either 35°C or 70°C using either isocratic or gradient elution with fluorescence end-point detection. The compounds were isolated from human plasma or serum by LLE or SPE techniques using... 

An alternative synthesis of 4-nitrodibenzothiophene involves heating 2-amino-2 -nitrodiphenyl sulfide in a sealed tube at 190° (20%). The reaction probably proceeds via homolytic cleavage of the derived diazonium ion which could have been formed from nitrous acid liberated during the formation of phenothiazines, which were also detected. Similarly, 2-methyl-4-nitrodibenzothiophene is formed from 2-amino-2 -nitro-4 -methyldiphenyl sulfide (10%), and in this case the intermediacy of the diazonium ion was further indicated in that the same material was obtained by pyrolysis of the separately prepared diazonium salt of the sulfide. Although yields are poor in this reaction, it nevertheless represents the only route to substituted dibenzothiophenes containing a nitro substituent in the 4-position and as such is worthy of further attention. 

Amino-5-nitro-1,2,3-triazole (ANTZ) (130), an explosive showing high thermal stability, has been synthesized via this route the reaction of sodium azide, acetaldehyde and 2,2-dinitroethyl acetate forming 4-methyl-5-nitro-1,2,3-triazole, which on conversion of the methyl group to an amino group yields ANTZ (130). Treatment of ANTZ (130) with hydrogen peroxide in sulfuric acid yields 4,5-dinitro-1,2,3-triazole (DNTZ) (131). 

Die 1-Aminierung mit O-Diphenylphosphinyl-hydroxylamin und Natriumhydrid in 1-Methyl-2-oxo-pyrrolidin ist sowohl fur wasserlosliche als auch fur wasserunlosliche Imidazole geeignet. Auch hier werden die Produkte iiblicherweise iiber die 1-Benzylidenamino-imidazole ge-reinigt. Auf diese Weise werden 1-Amino-611, l-Amino-4-nitro-611, l-Amino-2-methyl-4-ni(ro-611, l-Amino-2-methyl-61s und l-Amino-2-phenyl-imidazol678 hergestellt. 

Hydriert man 6-Acetylamino-4-hydroxy-7-(N-methyl-N-nitro-amino)-8-nitro-chinazolin, so wird die aromatische Nitro-Gruppe reduziert und die N-Nitro-Bindung gespalten. Bei der Zu-gabe von konzentrierter Salzsaure tritt Cyclisierung zu 9-Amino-1,2-dimethyl-5-hydroxy-lH-<,imidazo[4,5-g]chinazolin)-Hydrochlorid (80% Schmp. 326-327°) ein131 ... 

Auf ahnliche Weise konnen aus Amino-zuckern Nitro-zucker hergestellt werden. So erhalt man Methyl-3-nitro-2,3,6-trideoxy-3-c-methyl-a-D-ribo-hexopyranosid aus der ent-sprechenden Amino-Verbindung mit 3-Chlor-perbenzoesaure (Ausbeute 42%) ... 

H F3C-COOH 20 3 2- Amino-5-nitro-1-trifluor-methyl-... + 2-Amino-3-amino-l-tri-fluormelhyl-... 40 30 92 144 ... 

Die Photolyse einer sehr verdunnten, micellaren Losung von Benzanilid und seiner 4-Methyl- und 4-Nitro-Derivate in 0,01 molarem waBr. Natrium-dodecylsulfat fiihrt unter Fries-Verschiebung zur Bildung von 2-Amino- (80%), 2-Amino-5-methyl- (90%) bzw. 2-Amino-5-nitro-benzophenon (90%)l. 

OCH3, SH, NH2, CHg, or COOH,205 adenine-thymine base pair171,175,184, 185 and its cationic and anionic forms209 (for the charge densities at C-5 and C-6 positions in uracil, thymine, 5-amino- 5-nitro- and 6-methyl-uracil, 6-azathymine and orotic acid, see refs. 187, 188) it-HMO + a-Del Re calculations on uracil,369,397 5-fluoro- and 5-bromouracil,397 5,6-dihydrouracil and its anionic form369 n-SCF MO + a-Del Re... 

Methyl (9S,12S>12-[(terf-Butoxycarbonyl)(niethyl)amino]-4-nitro-ll-oxo-2-oxa-10-azatricyclo[12J.2.13-7]-nonadeca-l(16),3(19),4,6,14,17-hexaene-9-carboxylate (25) [251... 

The reaction of allenic nitrile and 2-amino-6-methyl- and -4,6-dimethyl-pyridine gave a mixture of mono- and bis-adducts tentatively formulated as 75, 76, and 77 [88JCS(P1)975], while 2-amino-3-nitro-, 2,6-diamino-, and 2-amino-3,5-dibromopyridines do not react even after refluxing for 120 hours. 

In addition, the following have been described as diazo components 2,5-dichloro-4-nitroaniline (red) [49], 2-chloro-5-trifluoromethylaniline (yellow) [50], 4-nitro-2-trifluoromethylaniline (red) [51], 2-amino-5-trifluoromethyl-l,3,4-thia-diazole (red) [52], 3-methylmercapto-5-amino-l,2,4-thiadiazole (red) [53], 3-methyl-4-nitro-5-aminoisothiazole (blue-violet) [54], 2-amino-6-chlorobenzothia-zole (red) [55], and 3-amino-5-nitro-7-bromobenzisothiazole (blue with a red cast) [56],... 

Chemical Name l,2,3,4-Tetrahydro-2-[[(l-methylethyl)amino]methyl]-7-nitro-6-quinolinemethanol... 

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