Nitric oxide synthesis inhibition

Pryor GT Persisting neurotoxic consequences of solvent abuse a developing animal modelfortoluene-inducedneurotoxicity. NlDAResMonogr 101 136—166,1990 Pudiak CM, Bozarth MA The effect of nitric oxide synthesis inhibition on intravenous cocaine self-administration. Prog Neuropsychopharmacol Biol Psychiatry 26 189— 196, 2002... 

Kapas, L., Fang, J. 8r Krueger, J. M. (1994a). Inhibition of nitric oxide synthesis inhibits rat sleep. Brain Res. 664, 189-96. 

Malmberg AB, Yaksh TL (1993) Spinal nitric oxide synthesis inhibition block NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain 54 291-300... 

Cases A, Haas J, Burnett JC, Romero JC Hemodynamic and renal effects of acute and progressive nitric oxide synthesis inhibition in anesthetized dogs. Am.J.Physiol Regul.Integr.Comp Physiol 280 R143-R148, 2001... 

Wang L, Kubodera S, Ueno A, Takeda M. Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats. Ren Fail 2001 23 11-19. 

Nijkamp, F.P., van der Linde, H.J. and Folkerts, G. (1993). Nitric oxide synthesis inhibition induces airway hyperresponsiveness in the guinea-pig in vivo and in vitro. Am. Rev. Respir. Dis. 148, 727-734. 

Kassab, S., Miller, M.T., Hester, R., Novak, J., and Granger, J.P. (1998), Systemic hemodynamics and regional blood flow during chronic nitric oxide synthesis inhibition in pregnant rats. Hypertension 57 315-320. 

Bostanci MO, Bagirici F (2008) Nitric oxide synthesis inhibition attenuates iron-induced neurotoxicity a stereological study. Neurotoxicology 29 130-135... 

Niu, X., Smith, C.W., Kubes, P., 1994. Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circulation Research 74, 1133-1140. 

Mouse peritoneal macrophages that have been activated to produce nitric oxide by 7-interferon and lipopolysac-charide were shown to oxidize LDL less readily than unactivated macrophages. Inhibition of nitric oxide synthesis in the same model was shown to enhance LDL oxidation (Jessup etal., 1992 Yates a al., 1992). It has recently been demonstrated that nitric oxide is able to inhibit lipid peroxidation directly within LDL (Ho etal., 1993c). Nitric oxide probably reacts with the propagating peroxyl radicals thus terminating the chain of lipid peroxidation. The rate constant for the reaction between nitric oxide and peroxyl radicals has recently been determined to be 1-3 X10 M" s (Padmaja and Huie, 1993). This... 

N5. Nava, E Palmer, M. J., and Moncada, S., Inhibition of nitric oxide synthesis in septic shock How much is beneficial . Lancet 338, 1555-1557 (1991). 

Lastra AL, Ramirez TO, Salazar L, Martinez M, Trujillo-Ferrara J. The ambrosanolide cumanin inhibits macrophage nitric oxide synthesis some structural considerations. J Ethnopharmacol 2004 95 221-227. 

Reactive nitrogen species are another factor of free radical damage in rheumatoid arthritis, although their role is less studied than that of oxygen radicals. Stichtenoth and Frolich [242] pointed out that the inhibition of nitric oxide synthesis had beneficial effects in humans. Mazzetti et al. [243] found that IL-1(3 stimulated NO production in RA chondrocytes. We demonstrated that NO synthase of RA neutrophils generated the enhanced amount of peroxynitrite [234]. Nitric oxide and oxygen radicals are also important inducers of death of human osteoarthritic synoviocytes [244]. 

Glutamine synthetase, a brain Mn enzyme, is located mainly in astrocytes, and its synthesis may be modulated by nitric oxide (496). Inhibition of this enzyme could be relevant to aging diseases (497). There is evidence that human NT2-N neurons die via ionotropic glutamate receptor-mediated mechanisms when exposed to hypoxia in the presence of glutamate (498). 

Macrophages were simutated with phorbol 1 Z-myristate 13-acetate, and nitric oxide synthesis was inhibited with N-methyl-L-arginine. Percent NO, represents the percentage of NO, compared... 

D. Inhibition of Nitric Oxide Synthesis in Cocultures by FK506... 

Flurbiprofen is a propionic acid derivative with a possibly more complex mechanism of action than other NSAIDs. Its (S)( ) enantiomer inhibits COX nonselectively, but it has been shown in rat tissue to also affect tumor necrosis factor- (TNF- ) and nitric oxide synthesis. Flepatic metabolism is extensive its (R) +) and (S) ) enantiomers are metabolized differently, and it does not undergo chiral conversion. It does demonstrate enterohepatic circulation. 

Zhao Q, Egashira K, Inoue S, Usui M, Kitamoto S, Ni W, Ishibashi M, Hiasa Ki K, Ichiki T, Shibuya M, Takeshita A (2002) Vascular endothelial growth factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric oxide synthesis. Circulation 105(9) 1110—1115... 

Calapai, G. et al., Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis, Life Sci., 67, 2673-2683, 2000. 

Recent investigations have shed light on peculiarities of the NOS action mechanism the role of the H4B cofactor and CaM, and cooperativity in kinetic and thermodynamic properties of different components of the nitric oxide synthesis system. Stop flow experiments with eNOS (Abu-Soud et al., 2000) showed that calmodulin binding caused an increase in NADH-dependent flavin reduction from 0.13 to 86 s 1 at 10 °C. Under such conditions, in the presence of Arg, heme is reduced very slowly (0.005 s 1). Heme complex formation requires a relatively high concentration ofNO (>50 nM) and inhibits the entire process NADH oxidation and citrulline synthesis decreases 3-fold and Km increases 3-fold. NOS reactions were monitored at subzero temperatures in the presence of 50% ethylene glycol as an anti-freeze solvent (Bee et al., 1998). 

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