Nitric oxide cerebellum

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Mayer, B., John, M., and Bohme, E. (1990a). Purification of aCa /calmodulin-dependent nitric oxide synthase from porcine cerebellum. FEBS Lett. 277, 215-219. 

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The CNS contains a substantial amount of nitric oxide synthase (NOS), which is found within certain classes of neurons. This neuronal NOS is an enzyme activated by calcium-calmodulin, and activation of NMDA receptors, which increases intracellular calcium, results in the generation of nitric oxide. Although a physiologic role for nitric oxide has been clearly established for vascular smooth muscle, its role in synaptic transmission and synaptic plasticity remains controversial. Perhaps the strongest case for a role of nitric oxide in neuronal signaling in the CNS is for long-term depression of synaptic transmission in the cerebellum. 

Frisch C, Dere E, Silva MA, Godecke A, Schrader J, Huston JP (2000) Superior water maze performance and increase in fear-related behavior in the endothelial nitric oxide synthase-deficient mouse together with monoamine changes in cerebellum and ventral striatum. J Neurosci 20 6694-700... 

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Pisu MB, Guioli S, Conforti E, Bernocchi G (2003) Signal molecules and receptors in the differential development of cerebellum lobules. Acute effects of cisplatin on nitric oxide and glutamate systems in Purkinje cell population. Brain Res Dev Brain Res 145 229-240. 

Crepel F, Jaillard D (1990) Protein kinase, nitric oxide and long-term depression of synapse in the cerebellum. Neuroreport, 1, 133-136. 

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Llansola M, Minana MD, Montoliu C, Saez R, CoRBALAN R, Manzo L and Felipo V (1999) Prenatal exposure to aluminum reduces expression of neuronal nitric oxide synthase and of soluble guanylate cyclase and impairs glutamatergic neurotransmission in rat cerebellum. J Neurochem 73 712-718. 

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