Nimesulide

C2H3CIO 75-36-5) see Acebutolol Acetiamine Acetylcholine chloride L-Alanine Benfurodil hemisuccinate . Chlorprothixene Flumetasone Ibuprofen lotalamic acid loxitalamic acid Levodopa Methestrol dipropionate Midecamycin acetate Naproxen Nimesulide Paclitaxel Paramethasone Phensuximide Retinol Rocuronium bromide Rofecoxib Ropinirole Tazarotene Thiopropazate Tiracizine Vecuronium bromide... 

Meolxicam and nimesulide, known as preferential inhibitors of COX-2, are usually well tolerated by AIA patients when given at low doses. Higher doses can elicit reactions. 

Ajayakumar P.V. Chanda D. Pal A. Singh M.P. Samad A. FT-NIR spectroscopy for rapid and simple determination of nimesulide in rabbit plasma for pharmacokinetic analysis. Journal of Pharmaceutical and Biomedical Analysis, 2012, 58 (1), 157-162. 

Sources (1) Michaux C, et al. A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide, European Journal of Medicinal Chemistry 40 1316-1324 (2005). (2) Stix G. Better ways to target pain, Scientific American January 84-88 (2007). 

Test of Octanol Titration Procedure. In order to see how close we were to reality with these titrations, the antiinflammatory sulfonanilide, R-805, nimesulide, was examined because the anion has a distinctive UV absorption. R-805 has pKa 5.9, log P 2.6, and a pKa in octanol of 8.82. With this data the log for the sodium salt is calculated from Equation 9 to be -0.3. R-805... 

Betulinic acid, an anticancer drug, the NS AID diclofenac and the cyclo-oxygenase 2 inhibitor nimesulide have all been shown to trigger MPT, leading to hepatotoxicity. 

Nimesulide is a NSAID of the sulfonanilide class. Nimesulide has exhibited potency... 

It is indicated in the treatment of a variety of painful inflammatory conditions, including osteoarthritis, oncology, postopera-tively, trauma, sports injuries, ear, nose and throat disorders, dental surgery, bursitis/ tendinitis, thrombophlebitis, upper airways inflammation and gynaecological disorders. Nimesulide has shown to be well tolerated even by aspirin sensitive asthmatic patients. 

Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of three inhibitors of inflammatory activity, Ketoprofen, Piroxicam, and Nimesulide, in supercritical CO2, measured using a dynamic saturation technique, were reported at pressures between 100 bar and 220 bar and at two temperatures 312.5 K and 331.5 K. The solubilities exhibit a clear dependence on the solvent density, and this has been used to provide a simple and precise correlation of the data (Macnaughton et al., 1996). 

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