Nimesulide, properties

Davis, R. and Brogden, R. N. Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, Drugs 1994, 48, 431-454. 

Although it is used in lotions, the marked degreasing properties of isopropyl alcohol may limit its usefulness in preparations used repeatedly. Isopropyl alcohol is also used as a solvent both for tablet film-coating and for tablet granulation, where the isopropyl alcohol is subsequently removed by evaporation. It has also been shown to significantly increase the skin permeability of nimesulide from carbomer 934. ... 

Terzano et al developed Polysorbate 20 niosomes containing beclomethasone dipropionate for pulmonary delivery to patients with chronic obstructive pulmonary disease. Singh et prepared niosomes containing the anti-inflammatory drug nimesulide and tested its physico-chemical properties including stability and in vitro release. It was shown that in vitro sustained drug release can be achieved with this approach. The research literature for niosomes in ocular drug delivery has been reviewed by Kaur et al." ... 

Trifluoromethanesulfonamides have been introduced in many biologically relevant compounds and represent important chemical motifs for the development of new pharmacophores. An illustrative example is given by the synthesis of a family of tri-fluoromethanesulfonamide analogues of Nimesulide that present inhibitory activity against cyclooxygenase-2 and in vivo antiinflammatory properties. Substitution of benzodiazepine derivatives by a trifluoromethanesulfonyl group enhanced their inhibitory activity toward mitochondrial ATP hydrolase. ... 

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