Nimesulide, structure

The compounds DuP 697, flosulide, nimesulide, etodolac, and NS-398, as shown in Table I, turned out to be Cox-2 selective inhibitors when examined by the assays described earlier and received considerable attention from various chemistry groups. Work on several structural series of Cox-2 selective inhibitors has been recently described from the medicinal chemistry point of view (Prasit and Riendeau, 1997)... 

Nimesulide is a sulfonanilide compound available in Europe that demonstrates COX-2 selectivity similar to celecoxib in whole blood assays. Additional effects include inhibition of neutrophil activation, decrease in cytokine production, decrease in degradative enzyme production, and possibly activation of glucocorticoid receptors. Its structure is ... 

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