Nimesulide liver failure

Rodrigo L, de Francisco R, Perez-Pariente JM, Cadahia V, Tojo R, Rodriguez M, Lucena MI, Andrade RJ. Nimesulide-induced severe hemolytic anemia and acute liver failure leading to liver transplantation. Scand J Gastroenterol 2002 37(11) 1341-3. 

Liver Nimesulide-induced hepatotoxidty can occur, with serious and potentially fatal outcomes. Three cases of liver failure related to nimesulide have been reported 77, 78 ]. In a retrospective analysis from the Irish national liver transplant unit all recipients of a liver transplant for fulminant hepatic failure of unknown cause (1994-2007) were evaluated [79 ]. There were 32 patients with seronegative, non-paracetamol-induced liver failure. Nimesulide had been started within 6 months in six patients and was assessed as probably associated with liver injury in all of these cases. 

Page M, Christin F, Hayi-Slayman D, Baillon JJ, Ber CE, Delafosse B, Dumortier J, Rimmel6 T. Hepatite fulminante li6e i un traitement par nimesulide encore un cas et revue de la litt6rature. [Acute liver failure due to a treatment by nimesulide another case and review.] Ann Fr Anesth Reanim 2008 27(9) 742-6. 

Betrosian AP, Flevari K, Andrianakis I, Boudouri I, Douzinas EE. Severe hemolytic anemia and fatal hepatic failure associated with nimesulide. Dig Liver Dis 2009 41(1) 80. 

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