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Nicotinamidic acid

Stoichiometric ratio nicotinamide acid Co-crystallisation from solution 1 1 2 1 Co-crystallisation from the melt 1 1 2 1 Neat grinding 1 1 2 1 LAG 1 1 2 1... [Pg.164]

Coemymes effecting transfer of hydrogen. These include the pyridine nucleotides, nicotinamide-adenine dinucleolide and nicotinamide-adenine dinucleolide phosphate the flavin nucleotides such as flavin-adenine dinucleotide and lipoic acid. [Pg.105]

Ammonia reacts with the ketone carbonyl group to give an mine (C=NH) which is then reduced to the amine function of the a ammo acid Both mine formation and reduc tion are enzyme catalyzed The reduced form of nicotinamide adenine diphosphonu cleotide (NADPH) is a coenzyme and acts as a reducing agent The step m which the mine is reduced is the one m which the chirality center is introduced and gives only L glutamic acid... [Pg.1124]

VITALES-NIACDIE,NICOTINAMIDE AND NICOTINIC ACID] (Vol25)... [Pg.669]

Vitamin B3. See Vitamins, Niacin, Nicotinamide, and Nicotinic acid. [Pg.1058]

Niacin, nicotinamide, and nicotinic acid. Pantothenic acid,... [Pg.2]

Fig. 9. Glucuionic acid pathway. NAD = nicotinamide-adenine dinucleotide NADH = reduced nicotinamide—adenine dinucleotide ... Fig. 9. Glucuionic acid pathway. NAD = nicotinamide-adenine dinucleotide NADH = reduced nicotinamide—adenine dinucleotide ...
Pyridine carboxamide [98-92-0] (nicotinamide) (1) and 3-pyridine carboxylic acid [59-67-6] (nicotinic acid) (2) have a rich history and their early significance stems not from their importance as a vitamin but rather as products derived from the oxidation of nicotine. In 1867, Huber prepared nicotinic acid from the potassium dichromate oxidation of nicotine. Many years later, Engler prepared nicotinamide. Workers at the turn of the twentieth century isolated nicotinic acid from several natural sources. In 1894, Su2uki isolated nicotinic acid from rice bran, and in 1912 Funk isolated the same substance from yeast (1). [Pg.46]

The biological importance of these compounds stems from their use as cofactors. Both nicotinamide and nicotinic acid ate building blocks for coen2yme I (Co I), nicotinarnide—adenine dinucleotide (NAE)) (3) and coen2yme II (Co II), nicotinarnide—adenine dinucleotide phosphate (NAE)P) (4) (2). [Pg.46]

Nicotinic acid is an amphoteric soHd with needle-shaped crystals. It is less soluble than nicotinamide and its poor solubihty in diethyl ether can be... [Pg.48]

Key intermediates in the industrial preparation of both nicotinamide and nicotinic acid are alkyl pyridines (Fig. 1). 2-Meth5l-5-ethylpyridine (6) is prepared in ahquid-phase process from acetaldehyde. Also, a synthesis starting from ethylene has been reported. Alternatively, 3-methylpyridine (7) can be used as starting material for the synthesis of nicotinamide and nicotinic acid and it is derived industrially from acetaldehyde, formaldehyde (qv), and ammonia. Pyridine is the principal product from this route and 3-methylpyridine is obtained as a by-product. Despite this and largely due to the large amount of pyridine produced by this technology, the majority of the 3-methylpyridine feedstock is prepared in this fashion. [Pg.48]

The result of this biosynthesis is that the product is nicotinic acid mononucleotide rather than free nicotinic acid. Ingested nicotinic acid is converted to nicotinic acid mononucleotide which, in turn, is converted to nicotinic acid adenine dinucleotide. Nicotinic acid adenine dinucleotide is then converted to nicotinamide adenine dinucleotide. If excess nicotinic acid is ingested, it is metabolized into a series of detoxification products (Fig. 4). Physiological metabohtes include /V-methylnicotinamide (19) and A/-methyl-6-pyridone-2-carboxamide (24) (1). [Pg.50]

Both nicotinic acid and nicotinamide have been assayed by chemical and biological methods. Owing to the fact that niacin is found in many different forms in nature, it is important to indicate the specific analyte in question. For example, if biological assay procedures are used, it is necessary to indicate whether the analysis is to determine the quantity of nicotinic acid or if niacin activity is the desired result of the analysis. If nicotinic acid is desired, then a method specific for nicotinic acid should be used. If quantitation of niacin activity is the desired outcome, then all compounds (bound and unbound) which behave like niacin will assay biologically for this substance (1). [Pg.50]

In the case of nicotinamide, the color yield is often low. This problem can be circumvented by either hydrolysis to nicotinic acid or by conversion of the amide to a fluorescent compound. Treatment of nicotinamide with methyl iodide yields the quaternary ammonium salt, /V-methyl nicotinamide (5). Reaction of this compound with acetophenone yields a fluorescent adduct (49). Other carbonyl compounds have also been used (50—54). [Pg.51]

For more specific analysis, chromatographic methods have been developed. Using reverse-phase columns and uv detection, hplc methods have been appHed to the analysis of nicotinic acid and nicotinamide in biological fluids such as blood and urine and in foods such as coffee and meat. Derivatization techniques have also been employed to improve sensitivity (55). For example, the reaction of nicotinic amide with DCCI (AT-dicyclohexyl-0-methoxycoumarin-4-yl)methyl isourea to yield the fluorescent coumarin ester has been reported (56). After separation on a reversed-phase column, detection limits of 10 pmol for nicotinic acid have been reported (57). [Pg.51]

Owing to poor volatihty, derivatization of nicotinic acid and nicotinamide are important techniques in the gc analysis of these substances. For example, a gc procedure has been reported for nicotinamide using a flame ionisation detector at detection limits of - 0.2 fig (58). The nonvolatile amide was converted to the nitrile by reaction with heptafluorobutryic anhydride (56). For a related molecule, quinolinic acid, fmol detection limits were claimed for a gc procedure using either packed or capillary columns after derivatization to its hexafluoroisopropyl ester (58). [Pg.51]

As with many of the vitamins, biological assays have an important historical role and are widely used. For example, microbiological assays use l ctobacillusplantarum ATCC No. 8014 (57,59) or l ctobacillus arabinosus (60). These methods are appropriate for both nicotinamide and nicotinic acid. Selective detection of nictonic acid is possible if l euconostoc mesenteroides ATCC No. 9135 is used as the test organism (61). The use of microbiological assays have been reviewed (62). [Pg.51]

Nicotinamide and nicotinic acid occur in nature almost exclusively in the bound form. In plants, nicotinic acid is prevalent whereas in animals nicotinamide is the predominant form. This nicotinamide is exclusively in the form of NAD and NADP. [Pg.51]

Nicotinamide and nicotinic acid are prevalent in many common foodstuffs and are especially concentrated in brewer s yeast, wheat germ and fiver. [Pg.51]

Table 3. Nicotinic Acid and Nicotinamide (Vitamin B ) Content of Foodstuffs, mg/kg ... Table 3. Nicotinic Acid and Nicotinamide (Vitamin B ) Content of Foodstuffs, mg/kg ...
Both nicotinic acid and nicotinamide have been used in the enrichment of bread, flour, and other grain-derived products. Animal feed is routinely supplemented with nicotinic acid and nicotinamide. Nicotinamide is also used in multivitamin preparations. Nicotinic acid is rarely used in this appHcation. The amide and carboxyHc acid have been used as a hrightener in electroplating baths and as stabili2er for pigmentation in cured meats. [Pg.53]


See other pages where Nicotinamidic acid is mentioned: [Pg.217]    [Pg.136]    [Pg.217]    [Pg.136]    [Pg.274]    [Pg.274]    [Pg.274]    [Pg.284]    [Pg.668]    [Pg.729]    [Pg.1059]    [Pg.352]    [Pg.476]    [Pg.479]    [Pg.46]    [Pg.46]    [Pg.46]    [Pg.47]    [Pg.48]    [Pg.48]    [Pg.48]    [Pg.49]    [Pg.50]    [Pg.51]    [Pg.52]    [Pg.52]    [Pg.53]    [Pg.54]    [Pg.54]   
See also in sourсe #XX -- [ Pg.269 ]




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NIACIN, NICOTINAMIDE, AND NICOTINIC ACID

Niacin Nicotinamide Nicotinic acid

Nicotinamide adenine dinucleotide fatty acid biosynthesis

Nicotinamide adenine dinucleotide phosphate fatty acid metabolism

Nicotinamide adenine dinucleotide reduction of pyruvic acid

Nicotinamide coenzyme from nicotinic acid

Nicotinic acid and nicotinamide

Nicotinic acid mixture with nicotinamide

Nicotinic acid, nicotinamide

Nicotinic acid, nicotinamide phosphate

Pyridine-3-carboxylic acid amides nicotinamide

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