Depolarizing neuromuscular blockers

Drugs that may be affected by aminoglycosides include anticoagulants, digoxin, methotrexate, neuromuscular blockers (depolarizing and nondepolarizing). [Pg.1653]

Neuromuscular blockers depolarizing nemomuscular blocking agents effects may be increased with rivastigmine... [Pg.31]

Suxamethonium - neuromuscular blocker (depolarizing) adjunct to general anaesthesia... [Pg.330]

The answer is c. (Hardman, p 1022.) Pyrantel pamoate is an antihelminthic that acts primarily as a depolarizing neuromuscular blocker. In certain worms, a spastic neuromuscular paralysis occurs, resulting in the expulsion of the worms from the intestinal tract of the host. Pyrantel also exerts its effect against parasites via release of acetylcholine and inhibition of cholinesterase. [Pg.77]

Metrifonate is an organophosphorous compound that is effective only in the treatment of S. haematobium The active metabolite, dichlorvos, inactivates acetylcholinesterase and potentiates inhibitory cholinergic effects. The schistosomes are swept away from the bladder to the lungs and are trapped. Therapeutic doses produce no untoward side effects except for mild cholinergic symptoms. It is contraindicated in pregnancy, previous insecticide exposure, or with depolarizing neuromuscular blockers. Metrifonate is not available in the United States. [Pg.626]

Two general types of neuromuscular blockers are discussed here. They are classified according to those that depolarize the skeletal muscle cell when binding to the cholinergic receptor and those that do not.37... [Pg.144]

Decamethonium, a depolarizing neuromuscular blocker, is little used nowadays. A dose of 3 mg provides adequate relaxation for intra-abdominal surgery for about 15 minutes, supplements being required at intervals of 10-30 minutes. It is not as rapid in onset of action as suxamethonium. It is not hydrolysed by plasma cholinesterase, but is eliminated by the kidneys (1). [Pg.1054]

Neuromuscular blocking agents are structurally related to acetylcholine. They either block transmission by simulating an excess of acetylcholine (depolarizing neuromuscular blockers) or prevent depolarization by preventing acetylcholine from binding to its receptor on the motor end plate (non-depolarizing neuromuscular blockers). [Pg.140]

Indications Neuromuscular blockade, endotracheal intubation Category Non-depolarizing neuromuscular blocker Half-life initial 2 minutes terminal 20 minutes Clinically important, potentially hazardous interactions with amikacin, aminoglycosides, anesthetics, antibiotics, gentamicin, halothane, kanamycin, neomycin, piperacillin, streptomycin, tobramycin... [Pg.53]

Category Non-depolarizing neuromuscular blocker Half-life 22 minutes... [Pg.128]

Trade names Norcuron Vecuron Indications Adjunct to general anesthesia Category Non-depolarizing neuromuscular blocker Half-life 65-75 minutes... [Pg.609]

Muscle relaxants Non-depolarizing neuromuscular blockers Short-lasting muscle paralysis Pancuronium, atracurium... [Pg.234]

There are two types of neuromuscular blocking drugs used during surgery nondepolarizing neuromuscular blockers and depolarizing neuromuscular blockers. [Pg.235]

Examples of non-depolarizing neuromuscular blockers are pancuronium and atra-curium. [Pg.235]

Side effects of non-depolarizing neuromuscular blockers are mainly caused by histamine release and include flushing, increased heart rate, hypotension and bronchospasm. [Pg.235]

Atracurium - muscle relaxant (non-depolarizing neuromuscular blocker) adjunct to... [Pg.324]

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