Non-depolarizing neuromuscular blockers

Neuromuscular blocking agents are structurally related to acetylcholine. They either block transmission by simulating an excess of acetylcholine (depolarizing neuromuscular blockers) or prevent depolarization by preventing acetylcholine from binding to its receptor on the motor end plate (non-depolarizing neuromuscular blockers). [Pg.140]

Indications Neuromuscular blockade, endotracheal intubation Category Non-depolarizing neuromuscular blocker Half-life initial 2 minutes terminal 20 minutes Clinically important, potentially hazardous interactions with amikacin, aminoglycosides, anesthetics, antibiotics, gentamicin, halothane, kanamycin, neomycin, piperacillin, streptomycin, tobramycin... [Pg.53]

Category Non-depolarizing neuromuscular blocker Half-life 22 minutes... [Pg.128]

Trade names Norcuron Vecuron Indications Adjunct to general anesthesia Category Non-depolarizing neuromuscular blocker Half-life 65-75 minutes... [Pg.609]

Muscle relaxants Non-depolarizing neuromuscular blockers Short-lasting muscle paralysis Pancuronium, atracurium... [Pg.234]

Examples of non-depolarizing neuromuscular blockers are pancuronium and atra-curium. [Pg.235]

Side effects of non-depolarizing neuromuscular blockers are mainly caused by histamine release and include flushing, increased heart rate, hypotension and bronchospasm. [Pg.235]

Atracurium - muscle relaxant (non-depolarizing neuromuscular blocker) adjunct to... [Pg.324]

This acts presynaptically, via activation of ATP-sensitive potassium channels, to inhibit neuromuscular transmission and acts at the muscle membrane to inhibit muscle contraction. Prolongation of neuromuscular block has been reported in patients receiving lithium and depolarizing and non-depolarizing neuromuscular blockers. Hence, the combination of litbium and ECT is relatively contraindicated. [Pg.203]

This is a calcium-channel antagonist, which can produce potentiation of suxamethonium and non-depolarizing neuromuscular blockers at doses within the therapeutic range. Verapamil also exacerbates the increase in serum potassium levels after the administration of suxamethonium. To date, there are no established data about such interactions between other calcium-channel blockers and... [Pg.203]

Quinidine is a non-depolarizing muscle blocker and potentiates the effects of neuromuscular blocking drugs (80). [Pg.3000]

Like in the neuromuscular junction the neurotransmission can be inhibited either by receptor blockade (non-depolarizing) or by overstimulation (depolarizing) of the receptors. The alkaloid nicotine, in low doses, stimulates ganglia and the adrenaline release from the adrenal medulla. High doses lead to a continuous depolarization of the postsynaptic membrane and thereby to an inactivation of the neurotransmission. All ganglion blockers in clinical use were synthetic amines of the nondepolarizing type trimethaphan, hexamethonium and mecamylamide. [Pg.297]

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